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Completed

NCT Number: NCT07673003

Sevoflurane Versus Propofol for Laryngeal Mask Airway Placement in Children Undergoing Surgery

The goal of this clinical trial is to compare two commonly used anesthetic medicines, sevoflurane and propofol, for inserting a laryngeal mask airway (LMA) in children undergoing minor elective surgery. A laryngeal mask airway is a device placed in the throat to help children breathe safely during anesthesia.

The main questions this study aims to answer are:

* Does sevoflurane produce a faster onset of anesthesia than propofol? * Is there a difference between sevoflurane and propofol in the time required to achieve jaw relaxation for LMA insertion? * Is there a difference between the two medicines in the time required for successful LMA insertion?

The researchers hypothesize that children receiving sevoflurane will have a shorter induction time than those receiving propofol.

A total of 170 children aged 4 to 12 years who are undergoing minor surgical procedures below the umbilicus will participate in the study. Participants will be randomly assigned to receive either intravenous propofol or inhaled sevoflurane for induction of anesthesia.

During the procedure, the anesthesia team will measure the time taken to lose consciousness, the time required to achieve adequate jaw relaxation, and the time needed for successful insertion of the laryngeal mask airway. These measurements will help determine which anesthetic agent provides better conditions for LMA insertion in children.

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Key information

Conditions

General Anaesthesia Airway Control Airway Devices

Age range

4 year–12 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Children's Hospital and Institute of Child Health Multan

Multan, Punjab Province, 60000, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA physical status 1 and 2
  • Undergoing elective minor surgical procedures below umbilicus
  • Procedure lasting less than 60 min

Exclusion criteria

  • Recent respiratory tract infection
  • Bronchial asthma
  • Family history of malignant hyperthermia

Treatment and study plan

Propofol

Drug

Intravenous propofol 3 mg/kg bolus will be administered for induction of general anesthesia before LMA insertion in pediatric patients.

Sevoflurane

Drug

Sevoflurane 7% will be delivered via inhalation in a nitrous oxide/oxygen mixture (2:1) for induction of general anesthesia prior to LMA insertion in pediatric patients.

Primary outcomes

  1. Time to Induction of Anesthesia

    Time frame: From administration of the induction agent until loss of consciousness, assessed for up to 5 minutes after induction.

    Time (in seconds) measured from administration of the induction agent (propofol or sevoflurane) to loss of consciousness, defined as loss of verbal response and loss of eyelash reflex in pediatric patients undergoing elective surgery for laryngeal mask airway insertion.

Other outcomes

  1. Time to Jaw Relaxation

    Time frame: From administration of the induction agent until achievement of adequate jaw relaxation (mouth opening >4 cm), assessed for up to 5 minutes after induction.

    Time (in seconds) measured from administration of induction agent to adequate jaw relaxation, defined as sufficient mouth opening (>4 cm) allowing insertion of laryngeal mask airway.

  2. Time to Laryngeal Mask Airway (LMA) Insertion

    Time frame: From administration of the induction agent until successful laryngeal mask airway insertion, assessed for up to 5 minutes after induction.

    Time (in seconds) measured from administration of induction agent to successful insertion of laryngeal mask airway using standard technique.

Sponsors and collaborators

Lead sponsor

Children's Hospital and Institute of Child Health, Multan

Other Gov

Registry information

Official study title

Comparison of Sevoflurane and Propofol for Laryngeal Mask Airway Insertion in Children

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 29, 2026
Registry last updated
Jun 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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