Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventilation

Patients with acute respiratory failure (ARF) who were receiving mechanical ventilator support, had significant pleural effusion (both transudates and exudates) and drainage plan were evaluated. Decision to drain, timing and duration of drainage were made by primary physician according to the intensive care unit (ICU) protocols.The estimated amount of effusion (mL) was calculated as the maximum pleura-lung distance (mm) x 20 and significant effusion is accepted as ≥ 800 mL according to thoracic ultrasonography (USG) performed by the intensivist. The amount of effusion drained, mechanical ventilator parameters, arterial blood gas results and hemodynamic data were recorded before, at the 1st hour and at the end of drainage up to 30 days after drainage.

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Key information

Conditions

Respiration, Artificial Pathologic Processes Pathological Conditions, Signs and Symptoms Pleural Diseases Pleural Effusion Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases Ultrasonography

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients on mechanical ventilation due to acute respiratory failure
Estimated effusion > 800 ml according to USG
Have drainage plan according to ICU protocols decided by primary physician

Exclusion criteria

Have absolute drainage indication (empyema, hemothorax or chylothorax)
predicted duration of mechanical ventilation less than 72 hours
contraindications to drainage,
underlying disease, which prevents lung expansion (chest deformity, central atelectasis)
malignant effusions

Treatment and study plan

Drainage of the pleural effusion

Procedure

Other names: Thoracic Ultrasonography performed by USG certificated intensivist to the all subjects included in the study before drainage

Primary outcomes

Correlation between estimated and drained effusion volume

Time frame: 1- Estimated effusion volume just before the drainage (by ultrasonography calculated as described in brief summary) 2- Drained effusion volume just after the drainage is terminated up to 30 days after procedure.

Volume of the effusion estimated and drained was recorded (mL)
Change in Lung mechanics

Time frame: 1- Dynamic Compliance just before the drainage 2- Dynamic Compliance just after the drainage is terminated up to 30 days after procedure

Dynamic Compliance (mL/cmH2O)
Change in Oxygenation

Time frame: 1- PaO2/FiO2 just before the drainage 2- PaO2/FiO2 just after the drainage is terminated up to 30 days after procedure

PaO2/FiO2 (fraction of inspired oxygen)

Sponsors and collaborators

Lead sponsor

Dokuz Eylul University

Other

Registry information

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Jan 9, 2018
Registry last updated: Jan 9, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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