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NCT Number: NCT07506798

Impact of Combined Intravenous-Inhalational vs Inhalational Anesthesia on QoR-15 Recovery Scores in Gynecologic Surgery

This study aims to compare the effects of combined intravenous-inhalational anesthesia versus inhalational anesthesia alone on postoperative recovery in patients undergoing elective gynecologic surgery.

A total of 100 patients, aged 18-65 years and classified as ASA I-III, scheduled for elective gynecologic procedures at Sakarya University Faculty of Medicine Training and Research Hospital, will be included. The sample size was calculated based on the primary outcome, the Quality of Recovery-15 (QoR-15) score.

Patients will complete the QoR-15 questionnaire preoperatively, before knowing which anesthesia method will be applied. Postoperative QoR-15 scores will be collected on postoperative days 1 and 2, and intraoperative data will be obtained from anesthesia records.

The study evaluates postoperative recovery using QoR-15 scores, covering physical comfort, emotional state, psychological support, pain, and ability to perform daily activities. Higher scores indicate better recovery, whereas lower scores indicate impaired postoperative recovery.

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Key information

Conditions

Gynecologic Surgery Anesthesia Postoperative Recovery

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sakarya University Training and Research Hospital

Sakarya, 54290, Turkey (Türkiye)

Location status: Recruiting

Location contact

ayça taş tuna, Professor

CONTACT

[email protected]

905323004826

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18-65 years
  • Scheduled for elective gynecologic surgery at Sakarya University Faculty of Medicine Training and Research Hospital
  • Classified as ASA I-III
  • Able to understand and complete the QoR-15 questionnaire
  • Provided written informed consent

Exclusion criteria

  • Severe comorbidities (beyond ASA III)
  • Patients with advanced neurological disease or cognitive impairment
  • Known allergy to anesthetic drugs used in the study
  • Classified as ASA IV-V
  • Refusal to participate in the study
  • Emergency or urgent surgery

Treatment and study plan

Combined Intravenous-Inhalational Anesthesia

Drug

Patients will receive a combination of intravenous anesthetic agents and inhalational anesthetic gases during elective gynecologic surgery. The specific anesthetic drugs and doses will follow routine clinical practice. Postoperative recovery will be assessed using the Quality of Recovery-15 (QoR-15) questionnaire on postoperative days 1 and 2.

Inhalational Anesthesia Only

Drug

Patients will receive only inhalational anesthetic gases during elective gynecologic surgery, following routine clinical practice. Postoperative recovery will be assessed using the QoR-15 questionnaire on postoperative days 1 and 2.

Primary outcomes

  1. Postoperative recovery using QoR-15

    Time frame: Postoperative Day 1 and Postoperative Day 2

    Postoperative recovery will be assessed using the Quality of Recovery-15 (QoR-15) questionnaire, a validated patient-reported outcome measure. The questionnaire evaluates physical comfort, emotional state, psychological support, pain, and ability to perform daily activities. Higher scores indicate better recovery.

Secondary outcomes

  1. Postoperative pain score

    Time frame: Postoperative hours 6, 12, and 24

    Pain will be assessed using a standard numerical rating scale (0-10) at postoperative hours 6, 12, and 24. Higher scores indicate more pain.

  2. Postoperative nausea and vomiting (PONV) incidence

    Time frame: Postoperative hours 0-24

    Incidence of nausea and vomiting will be recorded in the first 24 hours after surgery.

  3. Length of stay in post-anesthesia care unit (PACU)

    Time frame: Postoperative period (PACU stay), assessed up to 10 days

    Duration of stay in PACU will be recorded in minutes from admission to discharge.

Study contacts

Contact information is provided by the study sponsor or research team.

melike kar ünlü, MD

CONTACT

[email protected]

905079790381

Sponsors and collaborators

Lead sponsor

Sakarya University

Other

Registry information

Official study title

Effects of Combined Intravenous-Inhalational Anesthesia Versus Inhalational Anesthesia on Postoperative Recovery in Gynecological Operations: A Comparison Based on QoR-15 Scores

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Apr 2, 2026
Registry last updated
Apr 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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