A RCT on the Preventive Effect of HFNC on Postoperative Pulmonary Complications in Patients With Gynecologic Neoplasms

This randomized con aims to enroll patients at high risk of developing post-operative pulmonary complications after gynecological surgery, the eligible patients will be randomly assigned to receive oxygen therapy via high-flow nasal cannula or conventional nasal cannula. The study primary outcome is the incidence of post-operative pulmonary complications, including postoperative hypoxemia, atelectasis, pneumonia, etc. Secondary outcomes are the improvement of postoperative oxygenation, antibiotic use, length of hospital stay, adverse events related to oxygen therapy, etc.

Inclusion criteria

• Patients with gynecologic Neoplasms, including benign gynecologic tumors and malignant gynecologic tumors, who are 18 to 90 years old and are scheduled for surgical treatment in our center shall receive plain chest CT scan within 1 week before surgery, and the estimated surgical time shall be ≥2 hours, and at least one of the following conditions shall be met:

• Assess respiratory risk in surgical patients in Catalonia (ARRSPC) ≥45 points;
• BMI≥30;
• Moderate to severe asthma;
• Moderate to severe chronic obstructive pulmonary disease (COPD);
• Smoking history ≥20 packs/year

Exclusion criteria

• Patients with lung metastasis of malignant tumor or primary lung malignant tumor;
• previous lung surgery or radiotherapy;
• the surgery involved segmental bowel resection.