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OpenTrials
Completed

NCT Number: NCT01791751

Impact of Clomiphene Citrate Administration During the Early Luteal Phase on Endocrine Profile in IVF Cycles

The purpose of this study is to evaluate the effect on LH levels of the 5-day CC administration during luteal phase in oocyte donors, to investigate whether the CC corrects the suppressed LH levels in the luteal phase and whether it prolongs the luteal phase in the agonist triggered antagonist cycles.

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Key information

Conditions

Female Infertility Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Infertility Infertility, Female Urogenital Diseases

Age range

18 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Clínica EUGIN

Barcelona, 08029, Spain

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Oocyte donors
  • 18-35 years old
  • BMI 18-29 Kg/m2
  • Normal basal hormonal levels
  • No contraceptive pill

Exclusion criteria

  • Polycystic ovarian syndrome (PCOS)
  • Previous participation in the study

Treatment and study plan

Clomifene citrate

Drug

Clomiphene citrate 100 mg daily for 5 days

Primary outcomes

  1. LH Levels (IU)

    Time frame: Luteal phase (up to 2 weeks)

Secondary outcomes

  1. Endometrial development (Noyes criteria)

    Time frame: Luteal phase (1 day)

Sponsors and collaborators

Lead sponsor

Fundació Privada Eugin

Other

Registry information

Official study title

Impact of Clomiphene Citrate Administration During the Early Luteal Phase on Endocrine Profile in Agonist Triggered GnRH Antagonist in Vitro Fertilization Cycles. Phase IV, Single-centre, Open-label, Controlled Clinical Trial.

Acronym: CLOFA

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Feb 15, 2013
Registry last updated
Feb 15, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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