Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage

The influenza A/H1N1v pandemic virus causes severe pneumonia that can lead to acute respiratory distress syndrome and death even in healthy young individuals. The respective roles of viral replication, bacterial infection and immune alterations of the host during such severe influenza H1N1v infection need to be clarified in order to optimize patients care. In this context, we aim to study immune and virological parameters in bronchoalveolar lavage fluid during severe influenza A/H1N1v infection with pulmonary involvement in intensive care unit. Results will be correlated to bacterial or viral pulmonary co-infections and to peripheral blood immune and virological parameters.

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Key information

Conditions

Influenza Acute Lung Injury Acute Respiratory Distress Syndrome Infections Influenza, Human Lung Diseases Lung Injury Orthomyxoviridae Infections Pathologic Processes Pathological Conditions, Signs and Symptoms RNA Virus Infections Respiration Disorders Respiratory Aspiration Respiratory Distress Syndrome Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

13 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Pitie-Salpetrière Hospital, Paris, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Suspected influenza A/H1N1 infection
Diffuse bilateral pneumonia <96h with acute lung injury or respiratory distress syndrome
Invasive or non-invasive ventilation in intensive care unit
Age > 13

Exclusion criteria

Other cause identified of acute lung injury or acute respiratory distress syndrome
Contraindicated bronchoalveolar lavage

Treatment and study plan

Primary outcomes

immunological parameters in blood and bronchoalveolar lavage fluid

Time frame: day 0 and day 5-7 of ventilation for both blood and BAL, day 30 and month 5 for blood

Secondary outcomes

virological parameters in nose, broncho-alveolar lavage and peripheral blood

Time frame: day 0 and day 5-7 of ventilation

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Collaborators

Assistance Publique - Hôpitaux de Paris
Institut Pasteur

Registry information

Official study title

Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage in Patients Requiring Mechanical Ventilation in Intensive Care Unit

Acronym: FluBAL

Important dates

Study start: 2009
Primary completion: 2011
Study completion: 2011
First posted: Mar 18, 2010
Registry last updated: Dec 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed