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OpenTrials
Completed

NCT Number: NCT04549142

Immune Tolerance Dysfunction in Pregnancy Due to Ambient Air Pollution Exposure

The purpose of this project is to study the effects of air pollution toxicants on pregnant mothers' immune health during and after pregnancy.

Using already collected samples, this study proposes to evaluate changes in immune function in response to air pollution with the use of innovative technologies, to identify the drivers of immune dysfunction and potential modifiable factors, and to determine how these immune findings are associated with pollution exposure and outcomes of disease.

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Key information

Conditions

Air Pollution Pregnancy

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Sean N. Parker Center for Allergy & Asthma Research at Stanford University

Palo Alto, California, 94304, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pregnant women: at 18-25 weeks gestation at time of eligibility screening and baseline visit

Exclusion criteria

  • Having smoked more than 50 cigarettes during pregnancy
  • A history of autoimmune diseases, HIV or cancer

Treatment and study plan

There is no intervention

Other

There is no intervention

Primary outcomes

  1. Difference in immune cell subset identity and function in pregnant vs. non pregnant women exposed to high vs. low pollution over time

    Time frame: 3 years

  2. Identify the epigenetic molecular mechanisms driving immune dysfunction in pregnancy vs. no pregnancy with high vs. low PM2.5 exposure over time

    Time frame: 3 years

  3. Map T cell receptor diversity to immune dysfunction in pregnancy vs non pregnancy with high vs. low PM2.5 exposure over time

    Time frame: 3 years

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Collaborators

  • Duke University
  • National Institute of Environmental Health Sciences (NIEHS)

Registry information

Official study title

Immune Tolerance Dysfunction in Pregnancy Due to Ambient Air Pollution

Important dates

Study start
2020
Primary completion
2023
Study completion
2023
First posted
Sep 16, 2020
Registry last updated
Jun 15, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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