The Risk of Adverse Pregnancy Outcomes for Long-term Exposure to Air Pollution in Pregnant Patients With Pulmonary Hypertension

With economic development and rapid urbanization, air pollution has become an increasingly severe public health concern. The risk of adverse pregnancy outcomes is significantly elevated for pregnant women complicated by pulmonary hypertension. However, no studies to date have specifically examined the impact of environmental factors on pulmonary hypertension in pregnant women, nor their subsequent birth outcomes. Therefore, investigating the correlation between them holds substantial clinical and public health significance.

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Key information

Conditions

Pulmonary Arterial Hypertension Air Pollution Cardiovascular Diseases Female Urogenital Diseases and Pregnancy Complications Heart Diseases Heart Failure Hypertension Hypertension, Pulmonary Lung Diseases Maternal Outcome Obstetric Labor Complications Obstetric Labor, Premature Pregnancy Complications Premature Birth Respiratory Tract Diseases Urogenital Diseases Vascular Diseases

Age range

18 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

The First Affiliated Hospital, Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

About this study

The purpose of the research is preliminary found that the correlation between air pollution and maternal outcomes in pregnant women with pulmonary arterial hypertension and provide useful information for managment of pregnant women in special ambient conditions.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Pregnant women with pulmonary hypertension who attended major medical centers included in this study from January 2013 to December 2022.

Complete medical records available; ② Pulmonary artery systolic pressure ≥ 35 mmHg by echocardiography or a confirmed diagnosis of pulmonary hypertension by right heart catheterization; ③ Residential address information available at the city (district, county) level or higher.

Exclusion criteria

① Unclear diagnosis and completely missing address information;

Incomplete medical records; ③ Lost to follow-up during pregnancy or within six weeks postpartum.

Treatment and study plan

Primary outcomes

1.main maternal outcome

Time frame: diagnosis of pregnancy to six months postpartum

including maternal death and heart failure

Secondary outcomes

Secondary maternal outcome events

Time frame: From delivery to 42 days postpartum

including other cardiac events: arrhythmia requiring treatment, thromboembolic event, myocardial infarction, stroke, pulmonary hypertension crisis and so on.

Other outcomes

2.main offspring events

Time frame: From delivery to 42 days postpartum

including fetal or neonatal death, prematurity, low birth weight, small for gestational age

Sponsors and collaborators

Lead sponsor

Wei Huang

Other

Registry information

Important dates

Study start: 2013
Primary completion: 2022
Study completion: 2022
First posted: Sep 10, 2025
Registry last updated: Sep 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed