NCT Number: NCT07366593
Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age
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Request Info1 year–6 year
All sexes
Observational
Badr university, Cairo, Egypt
descriptive, cross-sectional study analyzed baseline data from 40 children with DS and acute pneumonia enrolled prior to intervention in a larger trial. Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.
Time frame: Upon enrollment and prior to any intervention baseline data were collected
Immunoglobulins: Concentrations of IgG(mg/dl) IgA,(mg/dl) and IgM (mg/dl) were determined from serum using an automated nephelometer
Time frame: Upon enrollment and prior to any intervention baseline data were collected
Respiratory rate (breaths/minute) was determined by direct observation and counting of chest wall movements over one full minute
Time frame: Upon enrollment and prior to any intervention baseline data were collected
Peripheral oxygen saturation (%) was measured non-invasively via pulse oximetry
Time frame: Upon enrollment and prior to any intervention baseline data were collected
Total WBC count (thousands/mm³) was measured from a whole blood sample using an ADVIA 120 automated hematology analyzer
Contact information is provided by the study sponsor or research team.
Mona Mohamed Abdelkhalek, assistance prof
CONTACT
Mona Mohamed Abdelkhalek, assistance prof
CONTACT
Badr University
Other
Relationship Between Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis
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