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NCT Number: NCT06842368

Immediate Implant Placement Using Xenograft Mixed with Vitamin D Versus Hyaluronic Acid.

Immediate implant placement using xenograft as space filling material mixed with vitamin D versus hyaluronic acid in posterior mandible region This study aims to evaluate implant stability and density after placement of immediate implant and Xenograft mixed with Hyaluronic acid or Vitamin D at posterior mandible region

Recruiting

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of dentistry ,Cairo university

Cairo, Egypt

Location status: Recruiting

About this study

Dental implants in fresh extraction sockets and healed sites have a erratic morphology, creating a wide space defect between the implant and buccal alveolar bone. This defect is critical for implant success, known as a jumping gap. Proper management of this space is essential for esthetic and functional success. Studies show adequate bone fill can be achieved in jumping gaps, but wider gaps increase implant body exposure risk.

The application of biological mediators embedded in the biomaterial can induce specific cell and tissue response, which can improve bone quality and quantity. Dental research has focused on improving bone substitutes by morphologic or bio- chemical modification.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age: 18-60.

  • Systemically healthy patients indicated for single or multiple immediate implants in posterior teeth region.
  • Absence of any peri-apical pathosis.
  • Patients with intact buccal plate of bone.
  • Patients with adequate bone volume for the dental implant procedure.
  • Patient with good oral hygrine

Exclusion criteria

  • Heavy Smokers.
  • Systemic disease that may affect the final outcome of the surgical procedure.
  • No or poor patient's compliance.
  • Patients with psychological problems.
  • Pathology at the site of intervention.
  • Patient with vit d deficiency

Treatment and study plan

Hyaluronic Acid (HA)

Procedure

Hyaluronic acid is one of the essential components of extracellular matrix, which plays a predominant role in tissue morphogenesis, cell migration, differentiation, and adhesion. It has been recently reported that hyaluronic acid increases osteoblastic bone formation in vitro through increased mesenchymal cell differentiation and migration.

It has demonstrated that Hyaluronic acid not only acted as a carrier of growth factors and cell but also stimulated bone formation through chemotaxis, proliferation and differentiation of mesenchymal cells into osteoblasts.

Although Hyaluronic acid shares bone induction properties with growth factors as bone morphogenic protein 2 and osteopontin

Vitamin D

Procedure

It was shown that locally applied vitamin D3 in combination with bovine bone mineral matrix improved the bone formation and strengthened the site of the fracture in ovariectomized rats.

Local application of vitamin D3 also proved to be promising in promoting osteo- genesis and mineralization for restoration of bone defects. Grounding on this incites, it has been suggested that vitamin D3 might exert a positive local effect on alveolar bone regeneration

Primary outcomes

  1. Implant secondary stability

    Time frame: after 6 months

    To evaluate the implant stability by Any-check device.

Secondary outcomes

  1. Density of bone around implant

    Time frame: after 6 months

    Cone beam computed tomography CBCT

Study contacts

Contact information is provided by the study sponsor or research team.

AMMAR EIZ EDDIN

CONTACT

[email protected]

00201153383058

MOHAMED ASHRAF, phD

CONTACT

[email protected]

00201111186256

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Immediate Implant Placement Using Xenograft As Space Filling Material Mixed with Vitamin D Versus Hyaluronic Acid in Posterior Mandible Region: a Randomized Controlled Clinical Trial.

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 24, 2025
Registry last updated
Feb 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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