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NCT Number: NCT06863051

Effect of Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant

The objective of this study will be to compare between Immediate Implant grafted with xenograft and Alb-PRF gel versus xenograft with L-PRF.

Recruiting

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Key information

Conditions

Immediate Implant Placement

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kafrelsheikh University, Faculty of Dentistry

Kafr ash Shaykh, Kafrelsheikh, Egypt

Location status: Recruiting

Location contact

Enas Ahmed Elgendy, Dean of Faculty of Dentistry

CONTACT

[email protected]

0201003508797

Enas Ahmed Elgendy, Dean of Faculty of Dentistry

PRINCIPAL_INVESTIGATOR

About this study

The objective of this study will be to compare between xenograft with Alb-PRF gel and xenograft with L-PRF ( L-PRF Block ) in the aspects of :

  • Peri-implant vertical defect depth.
  • Crestal bone level.
  • Bucco-lingual bone width.
  • Keratinized tissue width

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

  • Inclusion criteria
  • The presence of non-restorable mandibular molar.
  • Patient 18-45 years old
  • Intact buccal and lingual walls
  • Good oral hygiene.
  • Prescence of sufficient restorative space.
  • Jumping gap more than 2 mm.
  • Exclusion criteria
  • Proximity of anatomical structures
  • Acute localized infection (suppuration at the surgical field)
  • Patients on chemotherapy or radiotherapy.
  • Patients who have systemic disorders (diseases) {diabetes mellitus, autoimmune disease, …etc},
  • Pregnant patients.
  • Smoking and Alcohols.
  • Presence of periapical pathology affecting the neighboring teeth.

Treatment and study plan

Immediate Implant Placement and Alb-PRF

Procedure

Immediate Implant Placement in lower molar region, Grafted with Xenograft and Albumin PRF Gel

Immediate Implant Placement and L-PRF

Procedure

Immediate Implant Placement in lower molar region, Grafted with Xenograft and L-PRF

Primary outcomes

  1. Vertical peri-implant bone level

    Time frame: Immediate Post-Operative and 6 months after surgery

    the distance between implant platform to the most coronal bone-implant contact

  2. Keratinized tissue Width

    Time frame: Immediate Post-Operative and 6 months after surgery

    Width of Keratinized tissue before and after surgery

  3. Crestal bone level

    Time frame: Immediate Post-Operative and 6 months after surgery

    distance between implant platform and bone crest

Secondary outcomes

  1. Implant Stability

    Time frame: Immediate Post-Operative and 6 months after surgery

    by Smart peg

  2. Bucco-lingual bone width

    Time frame: Immediate Post-Operative and 6 months after surgery

    it's measured with a line coinciding with implant platform

Study contacts

Contact information is provided by the study sponsor or research team.

Mostafa Mohamed Fayed, Demonstrator of Periodontology

CONTACT

[email protected]

0201004668099

Sponsors and collaborators

Lead sponsor

Kafrelsheikh University

Other

Registry information

Official study title

Clinical and Radiographic Evaluation of Xenograft With Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant Placement in Mandibular Molar Extraction Sites: Randomized Clinical Trial.

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Mar 7, 2025
Registry last updated
Aug 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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