IcoSApent ethyL to Slow Down Aortic VAlve Stenosis proGrEssion

Inclusion criteria

• Age > 50 years
• Mild to moderate AVS

Exclusion criteria

• Bicuspid aortic valve
• History of chest radiotherapy
• History of rheumatic fever
• Moderate to severe renal failure, defined as eGFR < 30 ml/min
• Hyperparathyroidism
• Paget's disease
• Diagnosis of (active) malignancy in last 5 years
• Anticipated or planned aortic valve surgery in the next 6 months
• Life expectancy <2 years
• Chronic atrial fibrillation
• Use of anticoagulant medication or dual antiplatelet therapy
• Known hypersensitivity to fish and/or shellfish
• Known hypersensitivity to soya
• Malabsorption syndrome and/or chronic diarrhea
• Women of childbearing potential who are unwilling or unable to use an acceptable method of birth control [such as oral contraceptives, other hormonal contraceptives (vaginal products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (condoms)] to avoid pregnancy for the entire study.
• Women who are pregnant or breastfeeding
• Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
• Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study