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NCT Number: NCT07081438

iCBT for Adult Obsessive-Compulsive Disorder

The goal of the study is to assess the feasibility, acceptability, and potential effects of therapist-guided internet-delivered cognitive-behavior therapy (iCBT) for adult obsessive-compulsive disorder, using a recently developed digital platform.

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Key information

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Although cognitive-behavior therapy (CBT) is a well-established first-line treatment for many mental disorders, very few patients receive it due to the shortage of trained professionals, the costs of face-to-face therapy, and geographic barriers. Therapist-guided internet-delivered CBT (iCBT) is a potential solution to this problem but is not generally available in our context.

The investigators plan to:

  • Develop a digital platform for the treatment of mental disorders using therapist-guided iCBT;
  • Assess the feasibility, acceptability, and potential effects of therapist-guided iCBT for adult obsessive-compulsive disorder (OCD) using the platform developed in Objective 1.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18 and 75
  • Internet access
  • Principal diagnosis of OCD, based on DSM-5
  • Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) Total Severity Score > 16
  • Ability to communicate in Spanish
  • For participants taking psychotropic medication for OCD: at least eight weeks on stable medication and willingness to stay on the same medication/doses for the 12 weeks of the study

Exclusion criteria

  • Estimated IQ < 70, as per the Vocabulary subtest of the Wechsler Adults Intelligence Scale for Children (WISC)
  • Eight or more previous sessions of CBT for OCD with an experienced therapist during the last 12 months
  • Ongoing psychological treatment for OCD
  • Diagnosis of organic brain disorder, intellectual disability, autism spectrum disorder, psychosis, bipolar disorder, low-weight anorexia nervosa, or alcohol/substance dependence
  • Immediate risk to self or others (e.g., suicidality)
  • Inability to communicate in Spanish
  • Low motivation to participate (i.e., the patient does not believe the therapy will be helpful at all)
  • Insufficient time to work on the treatment (about 30 minutes per day)

Treatment and study plan

ICBT

Behavioral

12-Week Therapist-Based iCBT for OCD (Adapted Version of OCD Net: https://therapistguide.webcbt.se/index.html)

Primary outcomes

  1. Feasibility (recruitment and retention rates and therapist burden)

    Time frame: From enrollment to the end of treatment at 12 weeks

    The investigators will assess feasibility by recording recruitment rates, retention rates, and therapist burden (time spent by the therapist sending emails, reviewing materials, etc.).

Other outcomes

  1. Acceptability (Treatment Acceptability/Adherence Scale, TAAS)

    Time frame: Immediately after the intervention

    The TAAS assesses satisfaction with treatment and adherence.

  2. Yale-Brown Obsessive-Compulsive Scale

    Time frame: Baseline and 12 weeks

    The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) evaluates the severity of obsessive-compulsive disorder symptoms in adults. It is a clinician-rated, 10-item scale, with each item rated from 0 (no symptoms) to 4 (extreme symptoms), resulting in a total score ranging from 0 to 40. The scale also provides separate subtotals for the severity of obsessions and compulsions.

  3. Clinical Global Impression (CGI)-Severity

    Time frame: Baseline and 12 weeks

    The CGI rates the severity of the patient's illness at the time of assessment on a 7-point scale, from 1 = normal to 7 = among the most extremely ill patients.

  4. Beck Depression Inventory

    Time frame: Baseline and 12 weeks

    The BDI assesses the severity of depressive symptoms in adolescents and adults.

  5. Negative Effects Questionnaire (NEQ)

    Time frame: Baseline, mid-intervention and 12-weeks

    The NEQ assesses potential negative side effects of the intervention.

  6. Obsessive-Compulsive Inventory Revised (OCI-R)

    Time frame: Baseline and after 12 weeks

    The OCI-R assesses obsessive-compulsive symptoms experienced over the past month. It is an 18-item self-report questionnaire covering six symptom dimensions: washing, checking, ordering, obsessing, hoarding, and neutralizing. Each item is rated on a 5-point scale (0 = not at all, 4 = extremely), reflecting the distress caused by the symptom during the past month.

Study contacts

Contact information is provided by the study sponsor or research team.

Maria Sagué, MD

CONTACT

[email protected]

34 +932 27 54 00

Miquel A Fullana, PhD

CONTACT

[email protected]

34+637908990

Sponsors and collaborators

Lead sponsor

Hospital Clinic of Barcelona

Other

Registry information

Official study title

Taking Psychiatry Online: Developing a Platform to Provide Internet-Delivered Cognitive-Behavior Therapy and Testing It in Obsessive-Compulsive Disorder

Acronym: icbtadultOCD

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jul 23, 2025
Registry last updated
Jul 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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