Feasibility of Modulating Cognitive Control in OCD

Inclusion criteria

• Current primary DSM-5 OCD diagnosis and current Y-BOCS total score of ≥16 (OCD group, only) or no current diagnosis of an emotional disorder, and no known history of OCD, PTSD, anxiety disorder(s), or recurrent major depressive disorder (Healthy participant group, only)
• 18-60 years of age
• ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent
• psychotherapy and/or psychiatric medication use remain stable for 6 weeks prior to study entry

Exclusion criteria

• Presence of current psychiatric diagnosis (healthy control group, only)
• active substance use disorder
• history of mania or hypomania, or lifetime presence of significant psychotic symptoms
• active suicidal or homicidal ideation
• use of medications known to reduce seizure threshold (e.g., stimulants)
• organic brain disease or injury representing a contraindication to TMS
• any health problems that would interfere with safe and/or practical study participation, including contraindications to TMS (e.g., seizure disorder, presence of metal hardware that would come in close contact with the discharging coil)
• current pregnancy or planning to become pregnant during the study period