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OpenTrials
Completed

NCT Number: NCT07089004

Hypomagnesemia and Its Clinical Outcome

Magnesium is an essential electrolyte involved in numerous physiological processes, including maintaining cellular integrity, regulating muscle tone, supporting cardiovascular function, and modulating immune responses. Despite its critical role, magnesium is often overlooked in clinical practice, earning it the title of the "forgotten electrolyte." Hypomagnesemia, defined as serum magnesium levels below 1.5 mEq/L, has been associated with adverse clinical outcomes such as increased mortality, prolonged ICU stays, and higher requirements for mechanical ventilation. Critically ill patients are particularly vulnerable to hypomagnesemia due to various underlying conditions, gastrointestinal losses, and renal complications. However, limited data are available from Bangladesh on the burden and clinical impact of hypomagnesemia in ICU settings. This study aims to assess the correlation between hypomagnesemia and clinical outcomes, including length of ICU stay, need for mechanical ventilation, and mortality among critically ill patients in a tertiary care ICU in Bangladesh.

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Key information

Conditions

Hypomagnesemia Critical Illness Disease Attributes Intensive Care Unit (ICU) Patients Pathologic Processes Pathological Conditions, Signs and Symptoms Scoring Systems

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Science and Technology Chittagong (USTC)

Chittagong, Khulshi, 4202, Bangladesh

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 years and above.
  • Patients admitted to the Intensive Care Unit (ICU).
  • Patients who have serum magnesium levels measured within 24 hours of ICU admission.

Exclusion criteria

  • Patients with known end-stage renal disease on dialysis.
  • Patients with a history of magnesium supplementation prior to ICU admission.
  • Pregnant women.
  • Patients with incomplete medical records or unavailable laboratory data.

Treatment and study plan

No intervention (observational study)

Diagnostic Test

Observational - Biochemical, Hematological and Clinical Scoring Assessments

Primary outcomes

  1. Association of Hypomagnesemia with ICU Mortality

    Time frame: From the date of ICU admission until the date of ICU discharge or death, assessed up to 60 days.

    To assess the relationship between low serum magnesium levels and all-cause mortality among critically ill ICU patients.

Sponsors and collaborators

Lead sponsor

Bangladesh Bioscience Research Group

Network

Collaborators

  • Bangladesh Medical University
  • Chattogram International Dental College
  • Chittagong Medical College and Hospital

Registry information

Official study title

Co-relation of Hypomagnesemia With Clinical Outcomes in Critically Ill Patients Admitted to a Tertiary Care ICU in Bangladesh

Acronym: Hypogamnesamia

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Jul 28, 2025
Registry last updated
Jul 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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