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OpenTrials
Completed

NCT Number: NCT04946123

Hyperthyroidism: Methimazole Plus L-carnitine and Selenium

The study aims to investigate the benefits of methimazole treatment in patients with hyperthyroidism, associated with supplementation of L-carnitine and Selenium.

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Key information

Conditions

Hyperthyroidism Endocrine System Diseases Thyroid Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Azienda Ospedaliero-Universitaria Città della scienza e degli studi di Torino

Torino, 10126, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of hyperthyroidism requiring therapy with methimazole

Exclusion criteria

  • Drug and alcohol abuse;
  • Pregnancy;
  • Medically uncontrolled psychiatric conditions;
  • Interfering therapies (lithium, interferone, TKI, amiodarone)

Treatment and study plan

L-carnitine+Selenium

Dietary Supplement

Supplementation with L-carnitine and Selenium

Primary outcomes

  1. Hyperthyroidism symptoms

    Time frame: Change from baseline QoL at 6 months of supplementation

    Improvement of the patients' quality of life through questionnaire

  2. Hyperthyroidism symptoms

    Time frame: Change from 6-months supplementation QoL at 12 months of intervention (end of study)

    Improvement of the patients' quality of life through questionnaire

Secondary outcomes

  1. TRAb

    Time frame: Four time points: baseline; after 3 months of supplementation; after 6 months of supplementation; end of the study (12 months)

    Change in serum TRAb (TSH receptor antibodies)

  2. TSH

    Time frame: Four time points: baseline; after 3 months of supplementation; after 6 months of supplementation; end of the study (12 months)

    Change in serum TSH (Thyroid stimulating hormone)

Sponsors and collaborators

Lead sponsor

Lo.Li.Pharma s.r.l

Industry

Registry information

Official study title

Association of Methimazole With L-carnitine and Selenium in Patients With Hyperthyroidism

Important dates

Study start
2021
Primary completion
2025
Study completion
2025
First posted
Jun 30, 2021
Registry last updated
Jun 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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