Hymovis™ Versus Placebo in Knee Osteoarthritis

Inclusion criteria

• Male or female ambulant outpatients ≥ 40 years of age with an active lifestyle:
• Has a medical history of OA symptoms confirmed at least 3 months prior to the screening visit with radiographic evidence of OA, Kellgren-Lawrence grade 2-3
• Discontinuation of any analgesic/NSAID therapy prior to baseline with no intent to resume during study

Exclusion criteria

• Clinically significant apparent large effusion of the target knee;
• Clinically significant valgus/varus deformities, ligamentous laxity or meniscal instability as assessed by the Investigator;
• Any musculoskeletal condition affecting the target knee that would impair assessment of the effectiveness in the target knee such as Paget's disease
• Medical history of anaphylactic reactions
• History of septic arthritis in any joint
• Females who are pregnant or breast-feeding