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OpenTrials
Completed

NCT Number: NCT03612245

Hygiene and Bucco-dental Status of Patients With Oral Streptococcal Endocarditis

Infective endocarditis (IE) is a rare (30 cases / million / year in France) and serious disease (20 % of deaths during hospitalization and 40 % after 5 years). The development of an IE results from the meeting between a bacteremia and a pre-existent heart disorder, most of the time valvular, allowing the transplant of the circulating bacteria and their multiplication in the endocardium. Recommendations of prophylactic antibiotic treatment have been established since 1954 for some medical, particularly dental procedures, at the origin of bacteremia. But this policy has recently been questioned because its efficacy has not been demonstrated.

The purpose of this study is identify the situations with risk, by comparing the oral health status and the hygiene of patients having an IE with oral streptococci to those in patients having an IE with microorganisms not of oral origin.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

It is a case-control observational study. The IE cases are recruited in hospitals participating to the french prospective observational "EI2008" cohort.

Cases are IE with oral streptococci whereas controls are IE with microorganisms not of oral origin.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Major patient
  • Definite IE caused by oral streptococci (case) or by non-oral pathogens (control)

Exclusion criteria

-

Treatment and study plan

Primary outcomes

  1. Oral health status

    Time frame: During the IE event

    Dental and periodontal evaluation by a dental surgeon or a stomatologist, according to a protocol of standardized examination

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Besancon

Other

Collaborators

  • Bichat Hospital
  • CHU de Reims
  • Central Hospital, Nancy, France
  • Pitié-Salpêtrière Hospital
  • Rennes University Hospital

Registry information

Acronym: EI-DENTS

Important dates

Study start
2008
Primary completion
2012
Study completion
2012
First posted
Aug 2, 2018
Registry last updated
Aug 2, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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