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Completed

NCT Number: NCT04430803

Hydrogen-rich Water for Molecular and Phenotypic Biomarkers of Aging

This study evaluates the effects of six-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in men and women aged 70 years and over.

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Key information

Conditions

Aging

Age range

70 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

FSPE Applied Bioenergetics Lab

Novi Sad, Vojvodina, 21000, Serbia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > 70 years
  • Free of acute disorders

Exclusion criteria

  • History of dietary supplement use during the past 4 weeks

Treatment and study plan

Hydrogen-rich water

Dietary Supplement

A tablet that produces hydrogen dissolved in a glass of water

Control Water

Other

A glass of tap water

Primary outcomes

  1. Change in TeloTAGGG Telomerase PCR activity in serum

    Time frame: Baseline vs. 6 months post-intervention

    Baseline vs. 6 months

Secondary outcomes

  1. Change in DNA methylation

    Time frame: Baseline vs. 6 months post-intervention

    Baseline vs. 6 months

  2. Change in blood concentration of advanced glycation end product

    Time frame: Baseline vs. 6 months post-intervention

    Baseline vs. 6 months

  3. Change in lipid peroxidation

    Time frame: Baseline vs. 6 months post-intervention

    Baseline vs. 6 months

  4. Change in serum FGF21

    Time frame: Baseline vs. 6 months post-intervention

    Baseline vs. 6 months

  5. Change in serum TET2

    Time frame: Baseline vs. 6 months post-intervention

    Baseline vs. 6 months

  6. Change in ADAS-Cog score (0-70 scale, higher scores indicating greater cognitive impairment)

    Time frame: Baseline vs. 6 months post-intervention

    Baseline vs. 6 months

  7. Change in facial wrinkling (0-100 scale; higher scores mean worse outcome)

    Time frame: Baseline vs. 6 months post-intervention

    Baseline vs. 6 months

  8. Change in maximal oxygen uptake estimated by step-in-place test

    Time frame: Baseline vs. 6 months post-intervention

    Baseline vs. 6 months

Sponsors and collaborators

Lead sponsor

University of Novi Sad, Faculty of Sport and Physical Education

Other

Registry information

Official study title

The Effects of Six-month Hydrogen-rich Water Intake on Molecular and Phenotypic Biomarkers of Aging in Men and Women Aged 70 Years and Over: a Randomized-controlled Trial

Acronym: H2AGE

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Jun 12, 2020
Registry last updated
Apr 27, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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