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Completed

NCT Number: NCT06722326

Hydrogen-rich Water and Appetite in Obesity

The main goal of this study is to investigate how dihydrogen supplementation impacts body composition, appetite, quality of life specific to obesity, and levels of the hormone GLP-1 in men and women with obesity. This randomized controlled trial aims to explore whether dihydrogen can improve these health indicators.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Applied Bioenergetics Lab

Novi Sad, Vojvodina, 26000, Serbia

About this study

The primary aim of this randomized controlled trial is to evaluate the effects of dihydrogen supplementation on body composition indices, appetite, obesity-specific quality of life, and circulating GLP-1 levels in obese men and women

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-65 years
  • Body fat > 30% in women and > 25% in men
  • Not physically active
  • Informed consent signed

Exclusion criteria

  • Major chronic disease and acute injuries
  • History of dietary supplement use during the past 4 weeks
  • History of obesity pharmaceuticals use during the past 8 weeks
  • No consent to randomization
  • Participation in other studies

Treatment and study plan

Dietary Supplement: Hydrogen-rich water

Dietary Supplement

Hydrogen-rich water with 12 mg of hydrogen per serving

Dietary Supplement: Control water

Dietary Supplement

Control water with 0 mg of hydrogen per serving

Primary outcomes

  1. Appetite

    Time frame: Change from baseline appetite at 8 weeks

    Total scores for appetite as assessed by the the Food Cravings Questionnaire (FCQ)

Secondary outcomes

  1. Obesity-related quality or life

    Time frame: Change from baseline total scores for obesity-related quality of life at 8 weeks

    Total scores for obesity-related quality of life as assessed by the The Impact of Weight on Quality of Life-Lite (IWQOL-Lite) questionnaire

  2. Body fat

    Time frame: Change from baseline body fat at 8 weeks

    Percentage of body fat as assessed by a multifrequency bioelectrical impedance analyzer

  3. Serum GLP-1

    Time frame: Change from baseline GLP-1 at 8 weeks

    Serum levels of glucagon-like peptide-1 (GLP-1)

Sponsors and collaborators

Lead sponsor

University of Novi Sad, Faculty of Sport and Physical Education

Other

Registry information

Official study title

The Effects of 8-week Hydrogen-rich Water Consumption on Body Composition, Appetite and Obesity-specific Quality of Life, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (Hydrappet): a Randomized Controlled Trial

Acronym: HYDRAPPET

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Dec 9, 2024
Registry last updated
Jan 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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