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Completed

NCT Number: NCT03846141

Hydrogen Inhalation for Health and Exercise Performance

In this randomized double-blind, placebo-controlled, crossover pilot trial, we evaluated the effects of 7-day H2 inhalation on exercise performance outcomes and serum hormonal and inflammation profiles in a cohort of young men and women.

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Key information

Conditions

Exercise Performance

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

FSPE Applied Bioenergetics Lab

Novi Sad, Vojvodina, 21000, Serbia

About this study

All participants were allocated to receive either gaseous hydrogen (4%) or placebo (room air) by 20-min once-per-day inhalation for 7 days, with wash-out period of 7 days to prevent the residual effects of interventions across study periods. The primary treatment outcome was the change in running time-to-exhaustion from baseline to day 7. Additionally, assessment of other exercise performance endpoints and clinical chemistry biomarkers were performed at baseline and after 7 days after each intervention.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18 -35 years Body mass index 20 - 25 kg/m2 Free of major diseases Physically active Must be able to give written informed consent

Exclusion criteria

Use of any dietary supplements within 4 weeks before study commences Abnormal values for lab clinical chemistry (> 2 SD)

Treatment and study plan

Placebo

Other

Inhalation of room air for 20 min per day during 7 days

Hydrogen

Other

Inhalation of 4% hydrogen for 20 min per day during 7 days

Primary outcomes

  1. Change in exercise performance

    Time frame: Change from baseline running time-to-exhaustion at 7 days

    Running time-to-exhaustion

Secondary outcomes

  1. Change in exercise performance

    Time frame: Change from baseline maximal voluntary isometric strength at 7 days

    Maximal voluntary isometric strength

  2. Change in clinical chemistry biomarker

    Time frame: Change from baseline serum insulin at 7 days

    Insulin

  3. Change in clinical chemistry biomarker

    Time frame: Change from baseline serum ghrelin at 7 days

    Ghrelin

Sponsors and collaborators

Lead sponsor

University of Novi Sad, Faculty of Sport and Physical Education

Other

Registry information

Acronym: HIHEP

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Feb 19, 2019
Registry last updated
Feb 20, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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