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NCT Number: NCT07474714

Hyaluronic Acid Injection in Idiopathic Carpal Tunnel Syndrome; is it Effective as Local Corticosteroids

This study compares the effectiveness of two types of local injections-Hyaluronic Acid (HA) and corticosteroids-for treating mild to moderate idiopathic Carpal Tunnel Syndrome (CTS). Sixty adult patients will be assigned to receive one of the two injections under ultrasound guidance. The goal is to see if HA is as effective as the standard corticosteroid treatment in improving symptoms and nerve function over a 3-month follow-up period.

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Key information

Conditions

Carpal Tunnel Syndrome (CTS) Carpal Tunnel Syndrome Cumulative Trauma Disorders Median Neuropathy Mononeuropathies Nerve Compression Syndromes Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Sprains and Strains Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Minia University Hosopital

Minya, 61111, Egypt

Location contact

Facility of Medicine Minia University

CONTACT

[email protected]

+20862342584

Fatma Ali, Prof

PRINCIPAL_INVESTIGATOR

Haidy Mohamed Osman, MD

PRINCIPAL_INVESTIGATOR

Yara Assem, MD

SUB_INVESTIGATOR

About this study

This is a prospective comparative 3-month follow-up study. Sixty adult patients diagnosed with mild or moderate idiopathic CTS by electro-diagnostic studies will be recruited from the Rheumatology and rehabilitation clinic at Minia University Hospitals, Egypt. Participants will be divided into two groups of 30: one receiving low molecular weight hyaluronic acid and the other receiving corticosteroids, both administered via ultrasound-guided perineural injection. Baseline and follow-up assessments at 1- and 3-months post-injection will include the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) scores, electro-diagnostic parameters (sensory and motor latencies, CMAP, etc.), and neuromuscular ultrasound examination (median nerve cross-sectional area, flattening ratio, etc.).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Numbness or pain in the Median Nerve (MN) distribution.
  • Nerve conduction studies (NCS) consistent with CTS as per the AANEM guidelines.
  • An MN cross-sectional area (CSA) at the wrist >12 mm²

Exclusion criteria

  • Patients with severe symptoms (indication for surgery).
  • Patients who show improvement on medical treatment.
  • Patients with previous surgical or injectional CTS treatment.
  • Coexistence of brachial plexopathy, or thoracic outlet syndrome.
  • Patients with infection at the site of injection.

Treatment and study plan

Low Molecular Weight Hyaluronic Acid

Drug

Ultrasound-guided perineural injection of low molecular weight Hyaluronic Acid.

Corticosteroid

Drug

Ultrasound-guided perineural injection of corticosteroids

Primary outcomes

  1. Change in Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) Scores

    Time frame: Baseline, 1 month, and 3 months post-injection

    Comparison of the BCTQ scores (symptom severity and functional status) between the Hyaluronic Acid and Corticosteroid groups.

  2. Change in Electro-diagnostic Parameters

    Time frame: Time Frame Baseline, 1 month, and 3 months post-injection

    Comparison of sensory and motor electrodiagnostic parameters between the two groups, including peak sensory latency (ms), sensory nerve action potential - SNAP (µV), sensory conduction velocity - SCV (m/s), distal motor latency (ms), compound muscle action potential - CMAP (mV), and motor conduction velocity - MCV (m/s).

  3. Change in Neuromuscular Ultrasound Examination Parameters

    Time frame: Baseline, 1 month, and 3 months post-injection

    Comparison of neuromuscular ultrasound parameters between the two groups, including the median nerve cross-sectional area (CSA) measured in mm², fascicular pattern, flattening ratio, and mobility of the median nerve.

Study contacts

Contact information is provided by the study sponsor or research team.

Haidy Mohamed Osman, Osman

CONTACT

[email protected]

+201097238632

Yara Assem Assem, MD

CONTACT

[email protected]

+201093383306

Sponsors and collaborators

Lead sponsor

Minia University Hospital

Other

Registry information

Official study title

Hyaluronic Acid Injection in Idiopathic Carpal Tunnel Syndrome; is it Effective as Local Corticosteroids? A Comparative Follow up Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 16, 2026
Registry last updated
Mar 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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