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NCT Number: NCT07707089

Evaluation of AI-Mouse Use in Patients With Hand and Wrist Conditions

People with hand and wrist conditions, such as carpal tunnel syndrome or hand injuries, often experience pain and discomfort when using a computer mouse. This study will evaluate a new artificial intelligence (AI)-assisted computer input system ("AI-mouse") designed to reduce the amount of hand movement needed during computer tasks. Participants will complete short computer-based tasks using both a conventional mouse and the AI-assisted system while researchers measure task performance, muscle activity using surface electromyography (EMG), and participants' ratings of pain, physical strain, and usability. The study aims to determine whether the AI-assisted system can reduce physical effort and muscle load while maintaining effective computer interaction. Findings may help improve accessible computer technologies and support the development of ergonomic tools for people with hand and wrist impairments.

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Key information

Conditions

Carpal Tunnel Syndrome (CTS) Arm Injuries Carpal Tunnel Syndrome Cumulative Trauma Disorders Hand Injuries Median Neuropathy Mononeuropathies Nerve Compression Syndromes Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Sprains and Strains Wounds and Injuries Wounds and Injuries, Hands Wounds and Injuries, Wrists Wrist Injuries

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18-65 years
  • Diagnosis of a hand or wrist condition, including carpal tunnel syndrome or hand/wrist injury.
  • Receiving care at the Hand Surgery Department of the National Scientific Center of Traumatology and Orthopedics.
  • Medically stable and assessed by a study physician as able to safely perform light computer-based hand movements.
  • Able to understand the study procedures and provide written informed consent.
  • Normal or corrected-to-normal vision sufficient to complete computer-based tasks.

Exclusion criteria

  • Severe pain or acute symptoms that may be aggravated by computer task performance.
  • Postoperative restrictions limiting hand or wrist movement.
  • Severe motor impairment preventing completion of the study tasks.
  • Cognitive or neurological disorders that interfere with understanding study procedures or task performance.
  • Uncorrected visual impairment that interferes with computer use.
  • Any medical condition that, in the opinion of the study physician, would make participation unsafe.

Treatment and study plan

AI-Assisted Computer Input System

Device

A non-invasive computer input system that uses artificial intelligence to predict the user's intended on-screen action. Instead of relying primarily on continuous cursor movement and mouse clicking, the system presents predicted actions that participants can preview, accept, or discard using minimal keyboard input. The intervention is designed to reduce repetitive hand movements during computer interaction while preserving user control. Participants complete standardized computer tasks using the system during a single study session lasting less than four minutes.

Conventional Computer Mouse

Device

A standard computer mouse used for conventional point-and-click interaction. Participants complete the same standardized computer tasks as in the experimental condition, allowing direct comparison of task performance, upper-limb muscle activity measured by surface electromyography (EMG), and participant-reported pain, physical strain, and usability.

Primary outcomes

  1. APDF90 surface electromyography (sEMG) amplitude

    Time frame: Baseline (during each intervention condition on Day 1)

    90th percentile amplitude probability distribution function (APDF90) of the processed sEMG envelope recorded from selected upper-limb muscles during standardized computer tasks.

  2. Muscular rest time

    Time frame: Baseline (during each intervention condition on Day 1)

    Percentage of task duration during which the processed sEMG envelope remained below the predefined muscular-rest threshold of 2 µV.

Secondary outcomes

  1. Integrated squared dynamic acceleration

    Time frame: Baseline (during each intervention condition on Day 1)

    Cumulative dynamic movement workload measured by tri-axial accelerometry and expressed as integrated squared dynamic acceleration (mG²·s).

  2. 90th percentile dynamic acceleration

    Time frame: Baseline (during each intervention condition on Day 1)

    Peak dynamic movement intensity measured by tri-axial accelerometry and expressed as the 90th percentile of dynamic acceleration (mG).

  3. Task completion time

    Time frame: Baseline (during each intervention condition on Day 1)

    Time required to complete the standardized computer task using the conventional mouse and the AI-assisted computer input system.

  4. Error rate

    Time frame: Baseline (during each intervention condition on Day 1)

    Percentage of incorrect target selections during the standardized computer task

  5. Self-reported pain

    Time frame: Immediately after each intervention condition on Day 1

    Participant-reported hand and wrist pain after completing each intervention condition, assessed using a numeric rating scale

Study contacts

Contact information is provided by the study sponsor or research team.

Dina Kalinina, MD

CONTACT

[email protected]

+77756238719

Jose Berengueres, PhD

CONTACT

[email protected]

+7 778 358 18 26

Sponsors and collaborators

Lead sponsor

Nazarbayev University

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 16, 2026
Registry last updated
Jul 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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