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Completed

NCT Number: NCT06176937

Hyaluronic Acid Gel in Ridge Preservation

hyaluronic acid gel applied at the extraction socket after extraction immediately to preserve the socket from post extraction resorption. hyaluronic acid has ability for osteogenesis and new bone formation.

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Key information

Conditions

Hyaluronic Acid Gel for Preservation the Extraction Socket

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Ain shams University

Cairo, Egypt

About this study

twenty-four patients with one hopeless tooth at least, first CBCt before extraction to evaluate the dimension of the socket, then atraumatic extraction of the tooth to preserve the bony wall of the socket, after extraction and curettage the socket applied hyaluronic acid gel inside the socket and applied collagen membrane to secure the socket. After 4 months of extraction, CBCt was done to evaluate the dimension of the socket and the effect of hyaluronic acid. Furthermore, The core biopsy was taken by trephine bur at the time of implant placement for evaluate the histological appearance of the bone to evaluate the secondary outcome. then after three months the crown was delivered as a prosthetic part.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adult patients as evidenced by Burkett's oral medicine health history questionnaire
  • Both genders.
  • Age from 20 -50 years old.
  • Having at least one hopeless teeth indicated for extraction.
  • Esthetic zone teeth (anterior or premolar).
  • Sockets type 1 or 2 .
  • Patient should agree to sign a written consent after the nature of the study will be explained.

-

Exclusion criteria

1- Smokers. 2- Pregnant and breast-feeding females. 3- Mentally retarded Patients. 4- Prisoners and handicapped patients. 5- Patients with malocclusion.

-

Treatment and study plan

Hyaluronic acid

Drug

Alveolar ridge preservation by atraumatic tooth extraction and socket curettage then application hyaluronic acid gel after extraction and covering the socket by collagen membrane.

empty socket

Other

Alveolar ridge preservation by atraumatic tooth socket without application any drug but just covering the socket by collagen membrane.

Primary outcomes

  1. clinical outcome

    Time frame: baseline(before extraction)/ four months later after extraction

    measurement clinical bone width of the socket by millimeter before and 4 months after extraction ...

  2. Radiographic measurement

    Time frame: baseline(before extraction)/ four months later after extraction

    Radiographic measurement of bone width by CBCt before and 4 months after extraction

  3. Radiographic measurement

    Time frame: baseline (before extraction)/ four months later after extraction

    Radiographic measurement of bone height by CBCt before and 4 months after extraction.

Secondary outcomes

  1. histological analysis

    Time frame: after 4 months of extraction at the time of implant placement.

    The bone biopsy will be taken by trephine bur. And evaluate bone quality.

  2. histomorphometric analysis

    Time frame: after 4 months of extraction at the time of implant placement.

    The bone biopsy will be taken by trephine bur. And evaluate bone quantity.

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Efficacy of Hyaluronic Acid Gel in Ridge Preservation After Tooth Extraction: A Randomized Controlled Clinical Trial With Radiographic and Histomorphometric Study

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Dec 20, 2023
Registry last updated
Dec 20, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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