Hyaluronic Acid Filler for Dorsal Finger Volume Loss

At Marmur Medical, subjects will be recruited and consented prior to any study evaluations or procedures; if subjects meet the inclusion/exclusion criteria, participants will be enrolled into this study. Informed consent will clearly say the use of hyaluronic acid filler for the treatment of dorsal finger volume loss is investigational. Subjects will also be compensated for their visits (initial and six follow-ups totalling seven visits). Pre and post treatment photographs will be taken. Subjects will be given lidocaine cream to apply to the area of injection for temporary numbing effect prior to injection (10-15 minutes). Ice packs will also be applied to the area temporarily for numbing effect just prior to injection. The patient's fingers will be injected with 0.5-2.0 mL of hyaluronic acid total at the level of the sub-dermal plane. The injected filler will be molded as needed to optimize the correction of the fingers. Syringes used and amount injected into each finger, as well as the total per hand, will be documented to the 0.1 mL increment (e.g. 3.4 mL). The expected volume needed is 1-2 syringes per subject initially. On Day 14, subjects will return for evaluation and possible touch-up of injectable hyaluronic acid filler if needed (at the injector's discretion). The expected volume needed may be 1-2 syringes per subject for touch-up.

The subjects will return for follow-up at all time-points as follows: day 14 (+/- touch-up hyaluronic acid injection if necessary), 6 weeks, 3/6/9/12 months. The patient and investigator(s) will assess the volume enhancement in the fingers. Subjects will be asked to rate their level of satisfaction with the treatment at follow-up visits (Global Satisfaction Assessment, Natural Look/Feel Scale). In addition, at the initial visit, subjects will be given a 30 day diary to fill out that will evaluate for symptomology after injection (pain, bruising, swelling, redness, sensitivity/tenderness, itching, lumps/bump development, temporary numbness, signs of vascular compromise or other/open comment box). The subject diary will be collected at the 3 month follow-up visit. Statistical analysis of the data gathered will be performed by an outside statistician using tests such as Wilcoxian signed-rank test (for two observations) or Friedman's test (for more than 2 observations) using STAT, version 13. All adverse events will be recorded at every follow-up visit. These events include: redness, swelling, tenderness, nodule development under the skin and restricted range of motion. More serious adverse events include: compartment syndrome, infection at injection site, Tyndall effect, persistent granulomatous change, injection necrosis, persistent erythema with edema, and vascular occlusion causing symptoms such as pain, numbness and necrosis.

Inclusion criteria

• Exhibit volume loss and/or increased laxity and wrinkling of the dorsal fingers as determined by the investigator (moderate to severe volume loss).
• 18 years of age or older at time of consent. May be male or female.
• Can be of any Fitzpatrick Skin Type (I-VI).
• Able and willing to give written informed consent and to comply with requirements of this study protocol. The consent form has been standardized in English. For those patients who do not read and understand English, a consent form will be standardized and provided in a language that they read and understand, if possible.

Exclusion criteria

• Children and adolescents (less than 18 years old)
• Subjects who are not willing or able to prove written consent.
• Individuals with any significant medical history including skin disorders and eating disorders.
• Subjects with previous and/or known hypersensitivity to lidocaine, hyaluronic acid, or any of their

preservatives, wasp/bee/hornet stings, and/or hyaluronidase.

• Subjects on any substances affecting blood coagulation (i.e. aspirin and other non-steroidal anti-

inflammatory drugs, warfarin, vitamin E, heparin).

• Subjects with known blood coagulopathies.
• Subjects with a compromise of local blood supply (i.e. recent surgery, severe scarring).
• Subjects with previous history of rheumatologic or collagen vascular disease.
• Subjects who have received semi-permanent or temporary filler in the fingers in the past 18

months.

• Subjects with any history of permanent filler in the fingers.
• Subjects with dorsal finger volume loss too severe to be treated in one treatment session.
• Female patients who are planning a pregnancy, currently pregnant or nursing.
• Failure to sign photographic consent forms.