Hyaluronic Acid Effect on Xenogenic Bone Healing

The aim of this study is to test the hyaluronic acid hydrogel impact on the healing acceleration of xenogenic bone substitutes used in ridge preservation.

Following tooth extraction, bone particles are mixed with the hyaluronic acid gel and grafted in the tooth socket. at the implant placement phase, a cone beam computer assisted tomography file is recorded in order to compare it with the baseline and a biopsy to evaluate the histological consequences.

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Key information

Conditions

Bone Resorption Bone Diseases Mouth Diseases Musculoskeletal Diseases Periodontal Diseases Stomatognathic Diseases Tooth Diseases Tooth Loss

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Saint-Joseph university, Beirut, Lebanon

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients in need of tooth extraction and willing to receive dental implants in the extraction site
Presence of two mono radicular teeth in need of extraction

Exclusion criteria

Patients with systemic diseases
Patients under 8 years and above 60 years.
Presence of endodontic or periodontal lesion in the extraction sites

Treatment and study plan

Ridge preservation: Tooth extration and immediat bone grafting in the socket

Procedure

Following the tooth extraction, the socket is filled with a mixture of xenogenic bone and hyaluronic acid and sealed with an epithelio-connective arrested from the maxillary palate

Primary outcomes

Radiological assessement of the boe resorption

Time frame: 4 months

the baseline if the CBCT is compared to the 4 months post-op to assess the bone resorption
Histomorphometric analysis

Time frame: 4 months

During implant placement, a bone biopsy is harvested and stained with different colorants to assess microscopically the biological healing

Sponsors and collaborators

Lead sponsor

Saint-Joseph University

Other

Registry information

Official study title

Hyaluronic Acid Effect on Xenogenic Bone Substitutes Healing During Ridge Preservations: A Radiological and Histomorphometric Study

Important dates

Study start: 2020
Primary completion: 2021
Study completion: 2021
First posted: May 6, 2020
Registry last updated: Apr 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed