High- Versus Low-calcium Water for Bone Health

The experimental study investigates which metabolic responses of calcium and parathyroid hormone are observable in blood and urine in a cohort of 41 healthy adults following a sequence of different exposures: low-calcium water first and high-calcium water afterward.

Completed

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Key information

Conditions

Orthopedic Disorder Bone Diseases Bone Resorption Calcium Metabolism Disorders Eating, Healthy Metabolic Diseases Musculoskeletal Diseases Nutritional and Metabolic Diseases Water-Electrolyte Imbalance

Age range

25 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

IRCCS Istituto Ortopedico Galeazzi

Milan, Italy

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Body mass index ≥ 18 and < 30
Maintenance of diet and physical activity lifestyle throughout the duration of the study
Acceptance of informed consent

Exclusion criteria

Consumption of water with calcium > 150 mg/L
Pregnancy (as established by self-declaration), breastfeeding, menopause
Inability to follow the study protocol
Cardiac, vascular, renal, and oncological disease
Neuropsychiatric disease, developmental disorders
Disease or past surgery affecting the gastrointestinal tract
Drugs that interfere with bone (e.g. corticosteroids) or with fluid balance (e.g. diuretics)

Treatment and study plan

Loading of low-calcium water first, then high-calcium water

Other

All cohort subjects are asked to consume water with less than 5 mg/L of calcium first, then are asked to consume water with at least 400 mg/L of calcium

Primary outcomes

Change of blood calcium levels

Time frame: Baseline and 2.5 hours

Change of calcium levels (mg/dL) from baseline and after 2.5 hours

Sponsors and collaborators

Lead sponsor

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Other

Registry information

Official study title

Metabolic Response to the Consumption of Waters With Different Calcium Content: a Cross-over Clinical Study

Important dates

Study start: 2023
Primary completion: 2026
Study completion: 2026
First posted: Mar 16, 2023
Registry last updated: Apr 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed