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NCT Number: NCT06236945

HUTT to Assess Cardiac Autonomic Nervous Function

Autonomic nervous system diseases can cause abnormalities in the circulatory system, leading to malignant arrhythmia and sudden cardiac death. Standardized, operable, and simplified diagnostic indicators are urgently needed to evaluate autonomic nervous function, particularly cardiac autonomic nervous function. The investigators use HUTT in order to provide data support for cardiac autonomic nervous system evaluation.

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Key information

Conditions

Autonomic Nervous System Diseases Nervous System Diseases

Age range

12 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Hospital Of Hebei Medical University

Shijiazhuang, Hebei, 050000, China

Location status: Recruiting

Location contact

Xuekun Li, Master

CONTACT

[email protected]

17798061926

About this study

In this study, 169 samples with vertical tilt test and 24-h Holter ECG data from February 13, 2023 to October 31, 2023 were selected. The AC, DC, and 24-h HRV were compared with the CASS to identify the indicators with the strongest correlation with the CASS sympathetic and vagus nerve scores. The best index was selected, and the score intervals were delimited. The sensitivity and specificity of the defined vagal and sympathetic intervals were analyzed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Vertical tilt test and 24-hour holter electrocardiogram were performed at the same time

Receive treatment in our hospital.

Exclusion criteria

Taking benzodiazepines or hypotensive drugs within 24 hours

Combined with mental illness, severe dementia, serious organ disease

Severe arrhythmia, deep breathing and poor coordination of Valsaval movements affected the interpretation of results.

Treatment and study plan

Primary outcomes

To find the indicators which are most correlated to the sympathetic and vagus nerves.

Time frame: February 13, 2023 to December 31, 2025

The investigators use HUTT and CASS score to find some indicators which are most correlated to the sympathetic and vagus nerves,so that can give data support to the clinical treatments

Study contacts

Contact information is provided by the study sponsor or research team.

Yan Ding, M.D.

CONTACT

[email protected]

18633889260

Sponsors and collaborators

Lead sponsor

The First Hospital of Hebei Medical University

Other

Registry information

Official study title

Composite Autonomic Scoring Scale and HUTT to Assess Cardiac Autonomic Nervous Function: A Preliminary Study

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Feb 1, 2024
Registry last updated: Sep 26, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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