Human Umbilical Cord Mesenchymal Stem Cells for Alport Syndrome

Inclusion criteria

• 3 years old ≤Age ≤ 12 years old;
• Meet the diagnostic criteria of Alport syndrome;
• Positive proteinuria or combined hematuria;
• Chronic kidney disease (CKD) stage: I-III stage children, that is, glomerular filtration rate greater than 60 ml/min.1.73m2;
• No history of infectious diseases within 1 week before treatment;
• Negative infectious disease screening;
• No allergic state and related clinical manifestations;
• Signed informed consent (children or their families).

Exclusion criteria

• Age <3 years or >12 years old;
• Alport syndrome patients with only microscopic hematuria and normal glomerular filtration rate;
• Patients with significantly reduced renal function, chronic kidney disease stage IV or V, Alport syndrome;
• Patients with other renal diseases;
• Have a history of severe allergic reactions or be allergic to 2 or more foods or drugs;
• Known allergy to stem cells or stem cell-derived products or ingredients in stem cell preparations;
• Have severe heart, liver, lung and other organ dysfunction or have tumors;
• Those with developmental malformations of the urinary system;
• Those with autoimmune diseases and regular use of immunosuppressants;
• Those with serious infectious diseases that are not under control;
• Those with a history of infectious diseases such as HBV, HCV, HIV, syphilis;
• History of surgery or acute trauma or blood loss exceeding 200ml within 3 months;
• Participated in other clinical studies within 3 months;
• Have received any cell product or derivative product treatment within 12 months;
• Other circumstances that the researcher deems inappropriate for inclusion.