Human Papillomatosis Genotyping of Children in Thailand

Recurrent respiratory papillomatosis is caused by human papilloma virus and is the most common benign laryngeal neoplasm in children. Although RRP is rarely fatal, the disease requires prolonged, extensive medical and surgical treatment, and causes physical and emotional suffering in affected children and their families. Although recurrent respiratory papillomatosis is a relatively unusual problem, it accounts for significant health are expenditures.The goal of management of RRP is control of the disease, preservation of the voice and prevention of major complication .The purpose of study will identify risk factors for more severe juvenile RRP through prospective evaluation of a pediatric population in Thailand by the employing a protocol that includes staging of disease severity , as well as HPV genotyping.

Objective:

• To identify the genotypes of HPV isolated from Thai RRP patients
• To compare staging and severity with HPV genotypes
• To correlate the following characteristics of the Thai RRP patients with the HPV genotypes

Inclusion criteria

• Patients have active laryngeal papillomatosis .
• Patients have developed this infection before the age of 18 years old.

Exclusion criteria

• Children whose families do not sign an informed consent to enter into study.
• Children whose families anticipate discontinuing care at a participating institution during the study period.