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NCT Number: NCT07606469

Human Neural Correlates of Multi-Timescale Inference

Adult epilepsy patients who are undergoing intracranial monitoring will participate in a simple behavioral task during the clinical recording period.

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Key information

Conditions

Cognition Brain Activity

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Colorado Anschutz

Aurora, Colorado, 80045, United States

About this study

The investigators will analyze recorded neural activity, eye movements, and behavioral responses from epilepsy patients undergoing intracranial monitoring with clinically-relevant microelectrodes in hippocampus that perform a decision-making task. The participants will perform 1 session of the task during their monitoring period. Behavioral responses will be fit to inference models to identify strategies subjects use, and neural recordings (neuronal firing and low frequency activity) will be correlated with task features by comparing results to those produced by randomized (bootstrapped) data. Neural activity and corresponding behavioral strategies for each participant will be used to refine theoretical recurrent neural network models of hippocampal engagement in multi-timescale inference.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Epilepsy patients undergoing intracranial electrode monitoring for uncontrolled seizures.
  • no lesions identified in the participants' brains
  • capable of giving consent

Exclusion criteria

  • seizure activity during task recording
  • electrodes in regions of interest are identified to be the seizure focus
  • task performance outside of the normal range as determined from online studies with healthy participants

Treatment and study plan

Decision-making task

Behavioral

Patients will be asked to play a decision-making game in which they hear a tone and must identify its source.

Eye tracking

Behavioral

Patients will have simultaneous eye-tracking performed while playing the decision-making game

Primary outcomes

  1. Pupil size changes with respect to task features

    Time frame: continuous recording during task, up to 30 minutes

    pupil size will be measured with a portable eye-tracking device and correlated with task features

  2. Behavioral Responses

    Time frame: Approximately 10 seconds per trial, up to 30 minutes total

    Patient selects one of two choices on each trial using the computer keyboard

  3. Intracranial electrode recordings to measure changes in brain activity during decision making

    Time frame: duration of the task, approximately 30 minutes

    Intracranial neural recordings from patients who are implanted with electrodes for clinical purposes tha take place during the decision-making task

Study contacts

Contact information is provided by the study sponsor or research team.

Tahra Eissa

CONTACT

[email protected]

(303) 492-6974

Sponsors and collaborators

Lead sponsor

University of Colorado, Boulder

Other

Registry information

Official study title

Neuronal Mechanisms of Human Cognition

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
May 26, 2026
Registry last updated
May 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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