LDX and Functional Magnetic Resonance Imaging (fMRI in Menopausal Women

Inclusion criteria

• Have no previous or present history of a DSM-IV psychiatric or substance dependence disorder within the previous year, according to the Structured Clinical Interview for Diagnosis- DSM-IV (SCID)-Non-Patient Version;
• Are within 5 years of last menstrual period (LMP);
• Have a follicular stimulating hormone level (FSH) of 20 IU/ml;
• Are able to give written informed consent;
• Must have clear urine toxicology screen upon recruitment;
• Are fluent in written and spoken English;
• Are right-handed;
• Negative urine pregnancy test if still menstruating.

Exclusion criteria

• Mini-mental status exam score of less than or equal to 24;
• Presence of a psychiatric disorder within previous year or a life time history of ADHD or psychotic disorder including bipolar disorder, schizoaffective disorder, and schizophrenia;
• Lifetime history of drug addiction or abuse, except nicotine;
• Regular use of other psychotropic medication;
• Regular use (more than once a week) of alcohol that is less than 3 drinks/day;
• Presence of a contraindication to treatment with stimulant medication unless the condition is controlled with medication; this would include the presence of uncontrolled hypertension, coronary disease, atrial fibrillation, and arrhythmia;
• History of seizures;
• History of cardiac disease including known cardiac defect or conduction abnormality;
• Abnormal electrocardiogram during screening;
• Use of estrogen therapy within previous 2 months;
• Current pregnancy or planning to become pregnant;
• Metallic implant;
• Claustrophobia.