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OpenTrials
Completed

NCT Number: NCT00626847

How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?

Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.

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Key information

Conditions

Primary Open Angle Glaucoma Eye Diseases Glaucoma Glaucoma, Open-Angle Ocular Hypertension

Age range

40 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Wills Eye Glaucoma Service

Philadelphia, Pennsylvania, 19107, United States

About this study

Four tubes of blood will be taken from 100 people. Of those, half will have primary open angle glaucoma (POAG) and the other half will be controls (normals), half will be caucasians and the other half will be african americans, half male and half female. All groups will have a routine ophthalmic eye exam, color vision, snellen vision, and visual field done.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 40 yrs
  • Caucasian or African American
  • Male or female with POAG, PACG, PXFG,
  • Normal

Exclusion criteria

  • Other ophthamic co-morbidities
  • Other ethnic groups
  • Unable to understand and give informed consent

Treatment and study plan

Primary outcomes

  1. The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma.

    Time frame: one blood draw

Sponsors and collaborators

Lead sponsor

Wills Eye

Other

Collaborators

  • Jefferson Medical College of Thomas Jefferson University
  • Thomas Jefferson University

Registry information

Official study title

Nuclear Genetic and Mitochondrial Influences in Glaucoma

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Feb 29, 2008
Registry last updated
Nov 21, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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