Homeopathic Treatment of Children Suffering From PFAPA

Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome is frequently diagnosed in young children. Fevers recurring at a nearly predictable rate every three to eight weeks are the signature symptom of PFAPA syndrome. PFAPA is an acquired autoinflammatory disorder, which recurs in association with at least one sign of aphthous stomatitis, pharyngitis, and cervical lymph node enlargement. The aim of this retrospective case report is to gain an impression of the course of disease during individualized homeopathic treatment in children suffering from PFAPA.

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Key information

Conditions

Periodic Fever Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hereditary Autoinflammatory Diseases Skin Diseases Skin Diseases, Genetic Skin and Connective Tissue Diseases

Age range

1 year–10 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Michael Frass

Vienna, 1100, Austria

About this study

In this retrospective study, the investigators collected the history and symptoms of 13 consecutive PFAPA patients. The investigators also described the individually chosen homeopathic medicinal products (HMPs) used, as well as the course of the disease. Clinical outcome of case reports was assessed using the "Modified Naranjo Criteria for Homeopathy-Causal Attribution Inventory". Eight points are taken as the threshold for the possible correlation between homeopathic therapy and improvement of symptoms or cure in chronic cases

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Children suffering from fever with at least one of the symptooms of PFAPA besides fever

Exclusion criteria

Parents not willing to sign informed consent.

Treatment and study plan

Homeopathic Globule

Drug

Homeopathic globules were administered after careful anamnesis

Primary outcomes

Periodic fever flares

Time frame: 30 months

Appearance of periodic fever flares

Sponsors and collaborators

Lead sponsor

Michael Frass

Other

Registry information

Official study title

Homeopathic Treatment of Children Suffering From PFAPA: a Retrospective Case Series.

Acronym: HOMPFAPA

Important dates

Study start: 2019
Primary completion: 2020
Study completion: 2023
First posted: Aug 16, 2023
Registry last updated: Aug 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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