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Completed

NCT Number: NCT04022707

High Speed Circuit Training and Cognition

The purpose of this research study is to see if a weight training program can make a positive change in participant fitness as measured by the ability to use oxygen and help the participant remember things.

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Key information

Conditions

Educational Control Resistance Training

Age range

60 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Laboratory of Neruomuscular Research and Active Aging, Coral Gables, Florida, United States

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About this study

The purpose of this research study is to see if a weight training program can make a positive change in cardiac fitness, that is a person's ability to use oxygen; and, if the program can help a person's memory, as measured by some standard tests. The researchers will also ask the participant to attend two sessions with researchers at the Bascom-Palmer Eye Institute so they can take pictures of the participants' eyes to see how training changes the number of blood vessels. This can be used by doctors and other clinicians to evaluate improvements blood flow to the brain due to training.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women between 60 and 85 years of age (inclusive)
  • Ability to provide informed consent
  • No medical contraindication to participation in an exercise program including unstable or active untreated major medical illness (i.e., cardiovascular disease, neurological or neuromuscular diseases, stroke, cancer, etc.).

Exclusion criteria

  • Existing muscle-skeletal injury
  • Mini-mental score <18
  • Enrolled in another exercise program
  • Unstable or active major medical illness
  • Answer "Yes" to any questions on the Elder PAR-Q
  • Pregnancy

Treatment and study plan

High-speed circuit resistance training

Other

The program will include three circuits of 11 exercises that target the upper and lower body. Training will gradually increase over the first three week from 1 to 3 circuits.

Other names: High-velocity circuit training

Educational Control

Other

Lectures on health and fitness

Other names: Control

Primary outcomes

  1. Changes in Cognition due to training

    Time frame: Baseline, Week 14

    The MoCA will be used to detect mild cognitive impairment in the participants. The total possible score is 30 points; a score of 26 or above is considered normal.

  2. Submaximal cycle ergometer test to measure aerobic capacity

    Time frame: Baseline, Week 14

    The Young Men's Club of America (YMCA) cycle ergometer test will be used to compute aerobic capacity using heart rate(HR). Predicted oxygen consumption will be computed using the HR of the last two consecutive workloads performed and the maximum workload. A maximal oxygen consumption of 36 milliliters per kilogram body weight per minute and above is considered excellent for men, while 30 milliliters per kilogram body weight per minute is considered excellent for women.

  3. Change in episodic memory

    Time frame: Baseline, Week 14

    The National Institutes of Health (NIH) Toolbox: Picture Sequence Memory Test measures episodic memory. Participants are asked to reproduce a sequence of pictures that is shown on the screen. Participants are given credit for each adjacent pair of pictures they correctly place (i.e., if pictures in locations 7 and 8 are placed in that order and adjacent to each other anywhere, such as slots 1 and 2, one point is awarded), up to the maximum value for the sequence, which is one less than the sequence length or 17.

  4. Change in attention and inhibitory control

    Time frame: Baseline, Week 14

    The NIH Toolbox Flanker test measures attention and inhibitory control. Participant focuses on a given stimulus while inhibiting attention to stimuli flanking it. This computed score ranges from 0-10, but if the score is less than 4, it indicates that the participant did not score high enough in accuracy (80 percent correct or less) to receive a reaction time score.

  5. Change in working memory

    Time frame: Baseline, Week 14

    The NIH Toolbox List Sorting test measures working memory. Participant recalls and sequences different visually and orally presented stimuli. List Sorting is scored by summing the total number of items correctly recalled and sequenced on 1-List and 2-List, which can range from 0-26.

  6. Change in speed of cognitive processing

    Time frame: Baseline, Week 14

    The NIH Toolbox Pattern Comparison Processing Speed test measures speed of processing. Participants discern whether two side-by-side pictures are the same or not, with 85 seconds to respond to as many items as possible. Items are simple so as to purely measure processing speed. The participant's raw score is the number of items answered correctly in 85 seconds of response time, with a range of 0-130.

  7. Changes in the power muscles can produce

    Time frame: Baseline, Week 14

    The participants will stand up and down 3 times with a thin string attached to the participant's belt. A total of five attempts will be performed by each participant, and the highest power output will be selected for use in the analysis.

  8. Change in retinal microvascular density as a marker of cortical changes

    Time frame: Baseline, Week 14

    Retinal microvascular density will be assessed using the Retinal Function Imager (RFI) scan protocol and Optical Coherence Tomography Angiography (OCTA). Pictures will be taken of the subject's retina as they look into a special self-contained camera system.

Secondary outcomes

  1. Changes in body fat-free mass

    Time frame: Baseline, Week 14

    Fat-free mass will be measured using a Tanita BC-418 bioelectrical impedance scale.

  2. Changes in body weight

    Time frame: Baseline, Week 14

    Body weight will be measured on an electronic scale

Sponsors and collaborators

Lead sponsor

University of Miami

Other

Registry information

Official study title

The Impact of Circuit Resistance Training on Cognition and Estimated Maximal Oxygen Consumption in Older Adults.

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Jul 17, 2019
Registry last updated
May 18, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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