Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07438535

High-Load, Low-Load, and Passive Blood Flow Restriction in Competitive Sprinters

This randomized clinical trial will include competitive male and female sprinters aged 16-30 years, recruited through purposive sampling. Participants will be randomly assigned to one of three groups: (A) HL-BFR (70-85% 1RM with BFR during sets), (B) LL-BFR (20-30% 1RM with BFR), or (C) Passive BFR (BFR applied between sets). The intervention will consist of a 6-week sprint-specific resistance training program performed thrice weekly, incorporating resisted sprints, barbell step-ups, hip thrusts, Nordic curls, and bounding exercises. Strength will be measured using 1RM testing, explosive power through countermovement and standing broad jumps, and sprint performance via 10m, 30m, and 100m timed sprints. Subjective exertion will be tracked using the sRPE scale.

The study aims to determine whether HL-BFR, LL-BFR, or passive BFR produces superior improvements in sprint performance and neuromuscular strength. It is hypothesized that HL-BFR may yield greater adaptations due to combined mechanical and metabolic stress, though LL-BFR and passive BFR may offer practical, low-impact alternatives.

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Punjab Sports Board

Lahore, Punjab Province, 547000, Pakistan

Location status: Recruiting

Location contact

Danish Hassan, PhD

CONTACT

[email protected]

03457946009

Muhammad Mubarak Janjua, MSPT*

PRINCIPAL_INVESTIGATOR

About this study

Blood Flow Restriction (BFR) training characterized by applying external pressure to occlude venous return during exercise has gained prominence in both rehabilitation and athletic conditioning due to its ability to stimulate muscle hypertrophy and strength gains with lighter mechanical loads. The physiological basis includes metabolic accumulation, cellular swelling, and increased motor unit recruitment, mimicking high-intensity training effects even with low loads .

Elite sprint performance demands a finely tuned combination of explosive strength, neuromuscular power, and sprint-specific endurance across different phases of the race (acceleration, maximal velocity, deceleration). While high-load resistance training (≥ 70% 1RM) has long been the gold standard for developing muscular strength and power , blood flow restriction (BFR) training-particularly in low-load protocols (20-40% 1RM)-has emerged as a low-stress alternative capable of eliciting comparable hypertrophy and strength gains.

A growing body of literature now highlights the capacity of both high- and low-load BFR training to improve explosive performance metrics, such as vertical jump, sprint speed, and rate of force development. A systematic review found that athletes undergoing BFR training experienced small to moderate yet significant improvements in jumps (SMD ≈ 0.36), sprints (SMD ≈ 0.54), and power output (SMD ≈ 0.72), surpassing traditional resistance training outcomes.

High-load resistance training (≥ 70 % 1RM) is the established standard for enhancing neuromuscular strength and power. Recent investigations have examined adding BFR to high-load protocols (high-load BFR), aiming to amplify metabolic stress and post-activation performance enhancement. Though the evidence is mixed-a systematic review of ≥ 60 % 1RM BFR protocols concluded that only some studies showed additional strength or hypertrophy benefits compared to non-BFR controls emerging data suggest that high-load BFR may offer acute increases in lifting velocity and small improvements in jump and sprint outcomes.

Among BFR strategies, low-load BFR (LL-BFR)-typically at 20-40% of one-repetition maximum (1RM)-has the most robust evidence base. Systematic reviews demonstrate that LL-BFR training can induce similar muscle hypertrophy and near-equivalent strength improvements compared to traditional high-load training . These benefits, coupled with lower mechanical stress, have made LL-BFR a preferred method in both clinical and performance settings. Meta-analyses report that while maximum strength gains are slightly lower than high-load training, power, jump, and sprint performance show no significant differences between low-load BFR and high-load resistance training.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 16-30 years
  • Competitive sprinters with at least 2 years of sprint-specific training
  • Healthy individuals without cardiovascular, metabolic, musculoskeletal, or neurological disorders
  • Willingness to participate in a 6-week training program

Exclusion criteria

  • Pregnancy or lactation
  • Cardiovascular, vascular, pulmonary, renal or metabolic disorders
  • Uncontrolled hypertension
  • Recent significant weight loss
  • Use of performance-enhancing drugs within past 2 months
  • Any medical condition preventing safe participation

Treatment and study plan

High-Load Blood Flow Restriction Training (HL-BFR)

Other

In the High-Load BFR group, participants will perform resistance exercises at 70-85% of one-repetition maximum (1RM) with BFR applied during exercise sets.

Low-Load Blood Flow Restriction Training (LL-BFR)

Other

In the Low-Load BFR group, participants will perform resistance exercises at 20-30% of one-repetition maximum (1RM) with BFR applied during exercise sets.

Passive Blood Flow Restriction Training (PBFR)

Other

In the Passive BFR group, participants will perform resistance exercises at 70-85% of one-repetition maximum (1RM) with BFR applied only during rest intervals between sets.

Primary outcomes

  1. Lower Limb Muscle Strength (1RM Test)

    Time frame: Baseline (Week 0) and Post-Intervention (Week 6)

    Maximum voluntary strength of lower limb muscles will be assessed using one repetition maximum (1RM) testing protocol for resistance training exercises.

Secondary outcomes

  1. Vertical Jump Height

    Time frame: Baseline (Week 0) and Post-Intervention (Week 6)

    Explosive lower limb power will be assessed using vertical jump performance test measured in centimeters.

  2. 10-Meter Sprint Time

    Time frame: Baseline (Week 0) and Post-Intervention (Week 6)

    Sprint performance over short distance will be measured using timing gates in seconds.

  3. 30-Meter Sprint Time

    Time frame: Baseline (Week 0) and Post-Intervention (Week 6)

    Sprint acceleration and performance will be measured using electronic timing system in seconds.

  4. 100-Meter Sprint Time

    Time frame: Baseline (Week 0) and Post-Intervention (Week 6)

    Overall sprint performance will be assessed using timing system in seconds.

  5. Participant-reported exertion during training sessions using Borg CR-10 Scale.

    Time frame: Throughout Intervention Period (Week 1-6)

    Participant-reported exertion during training sessions using Borg CR-10 Scale.

Study contacts

Contact information is provided by the study sponsor or research team.

Danish Hassan, PhD

CONTACT

[email protected]

+92 345 7946009

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Comparative Effects of High-Load, Low-Load, and Passive Blood Flow Restriction Training on Strength and Sprint Performance in Competitive Sprinters

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 27, 2026
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.