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Completed

NCT Number: NCT01058161

High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

The present project aims at evaluating the diagnostic potential of high-field MRI (3 Teslas) for joint disease. At this field, given that isotropic image resolution of 400 microns can be obtained, one could expect an early detection of joint abnormalities. The additional aim of this project will be to develop a quantitative analyse of the corresponding high-resolution images.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Assistance Publique Hopitaux de Marseille

Marseille, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • gp Suspects or affected by rheumatoid polyarthritis
  • Morning articular Stiffness of at least 15 minutes.
  • Arthalgias or Arthritises of at least three joints(articulations), among which those of the hand.
  • Possible rheumatoid Presence of a factor(mailman) and\\or Antibody anti peptides positive citrullinés.
  • Typical possible radiological Hurts on the standard clichés(pictures) of the reached(affected) joints(articulations).
  • gp Affected by stiffening spondylitis with axial and peripheral infringement :

. Lumbago and steepness lumbar vertebra inflammatory. 2. Arthralgias and\\or peripheral arthritises 3. Possible presence of an allèle HLA 4. Possible presence of a sacro-illite 5. Absence of the other rheumatic markers

  • gp Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis
  • gp Healthy control
  • gp Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

Exclusion criteria

  • Claustrophobia,
  • metallic foreign bodies,
  • pacemakers The pregnant women,
  • parturients or who breast-feed are excluded from the study

Treatment and study plan

high-field MRI (3 Teslas)

Other

high-field MRI (3 Teslas)

Primary outcomes

  1. can be obtained, one could expect an early detection of joint abnormalities

    Time frame: 24 months

Secondary outcomes

  1. will be to develop a quantitative analyse of the corresponding high-resolution images.

    Time frame: 24 months

Sponsors and collaborators

Lead sponsor

Assistance Publique Hopitaux De Marseille

Other

Registry information

Important dates

Study start
2009
Primary completion
2013
Study completion
2013
First posted
Jan 28, 2010
Registry last updated
Aug 28, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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