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Completed

NCT Number: NCT04266041

High-density EEG in Neurological Disorders

The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.

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Key information

Conditions

Epilepsy Behavior Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Communication Healthy Language Neoplasms Nervous System Diseases Stroke Tumor Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States

About this study

This study will measure brain waves using high-density EEG. Participants will be asked wear a cap with electrodes attached to it. During the recording, participants may be asked to rest, sleep, or complete a task. The tasks involve viewing pictures, answering questions, speaking, or moving an arm or leg. Recordings generally last between 60-120 minutes.*

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Able to perform the tasks
  • Able to give own consent

Exclusion criteria

  • Any neurologic or psychiatric diagnosis such as stroke, tumor, or psychosis judged to interfere with high-density EEG.

Treatment and study plan

high-density electroencephalogram (HD-EEG)

Diagnostic Test

This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.

Primary outcomes

  1. Localizing Brain Regions That Generate Interictal Spikes

    Time frame: From 30-60 min HD-EEG recording, pre-operatively

    The frequency of detecting interictal spikes in HD-EEG The distance between the source location determined by electrical source imaging and the spike locations determined by SEEG studies

Secondary outcomes

  1. Localize Brain Functions in Patients and Healthy Controls

    Time frame: At baseline for approximately 60 - 90 minutes

    Localize brain functions using high-density EEG recordings

  2. Localize Brain Areas Involved in Language

    Time frame: At baseline for approximately 60 - 90 minutes

    Localize brain areas involved in language using high-density EEG recordings

  3. Localize Brain Areas Involved in Movement

    Time frame: At baseline for approximately 60 - 90 minutes

    Localize brain areas involved in movement using high-density EEG recordings

  4. Localize Brain Areas Involved in Sensation

    Time frame: At baseline for approximately 60 - 90 minutes

    Localize brain areas involved in sensation using high-density EEG recordings

  5. Localize Brain Areas Associated With Lesions

    Time frame: At baseline for approximately 60 - 90 minutes

    Localize brain areas associated with lesions using high-density EEG recordings

Sponsors and collaborators

Lead sponsor

Dartmouth-Hitchcock Medical Center

Other

Registry information

Important dates

Study start
2018
Primary completion
2024
Study completion
2024
First posted
Feb 12, 2020
Registry last updated
Dec 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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