HIF-1 Alpha, VEGF and MMP-8 Levels in PICF of Smokers Versus Non Smokers

Smoking is a major risk factor for developing peri-implantitis so the current study is comparing inflammatory markers in smokers versus non smokers to know if they have a potential role in pathogenesis of peri-implantitis

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Key information

Conditions

Peri-implantitis Behavior Inflammation Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Smoking Stomatognathic Diseases

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of oral and dental medicine,FUE, Cairo,Egypt

Cairo, 11835, Egypt

About this study

Peri -implant crevicular fluid was obtained from seven smoker patients and then compared to peri-implant crevicular fluid from seven non smoker individuals.

The peri-implant crevicular fluid was obtained using periopaper strips then analyzed using ELISA kits of these markers; HIF-1 Alpha, VEGF and MMP-8

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Medically free patients
Individuals with restored implants placed one year or more before study enrollment
Both genders
Age range 20-50 years old

Exclusion criteria

Pregnant Females
Lactating females

Treatment and study plan

Primary outcomes

Measurement of levels of HIF-1 Alpha, VEGF and MMP-8 in peri-implant crevicular fluid

Time frame: Baseline

Markers collected using periopaper strips

Sponsors and collaborators

Lead sponsor

Future University in Egypt

Other

Registry information

Official study title

HIF-1 Alpha, VEGF and MMP-8 Levels in Peri-implant Crevicular Fluid of Smokers Versus Non Smokers

Important dates

Study start: 2021
Primary completion: 2022
Study completion: 2022
First posted: Apr 13, 2022
Registry last updated: Apr 14, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed