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NCT Number: NCT07530211

The Effect of Systemic Factors on Peri-implant Health Status and Clinical Indices

This cross-sectional study evaluates the impact of systemic risk factors, including diabetes mellitus, smoking, cardiovascular disease, and osteoporosis, on peri-implant health status and clinical indices. The study included 93 patients with a total of 314 implants that have been in function for at least three years. The primary goal is to determine how these systemic conditions influence the prevalence of peri-implant mucositis and peri-implantitis.

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Key information

Conditions

Peri-implantitis Behavior Bone Diseases Bone Diseases, Metabolic Cardiovascular Diseases Dental Implants Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Mouth Diseases Musculoskeletal Diseases Nutritional and Metabolic Diseases Osteoporosis Peri-implant Mucositis Periodontal Diseases Smoking Stomatognathic Diseases

Age range

27 year–72 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Inonu University Faculty of Dentistry

Battalgazi, Malatya, 44300, Turkey (Türkiye)

About this study

Clinical parameters, including Gingival Index (GI), Plaque Index (PI), and Probing Depth (PD), were measured using a standard periodontal probe. Radiographic assessments were performed to evaluate bone loss in accordance with European Periodontology Workshop guidelines. Peri-implant health status was categorized into three groups: healthy, peri-implant mucositis, and peri-implantitis. Data analysis was conducted using chi-square and Mann-Whitney U tests to examine the associations between systemic factors and peri-implant tissues.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with at least one dental implant in function for at least three years.
  • Patients aged between 27 and 72 years.
  • Availability of complete clinical and radiographic records.

Exclusion criteria

  • Implants in function for less than 3 years.
  • Pregnancy or lactation.
  • History of radiation therapy in the head and neck region

Treatment and study plan

Clinical and Radiographic Periodontal Assessment

Other

Clinical parameters (Plaque Index, Gingival Index, Probing Depth) and radiographic assessments were performed for each patient to determine peri-implant health status

Primary outcomes

  1. Prevalence of Peri-implant Diseases

    Time frame: Minimum 3 years post-loading veya At clinical assessment, at least 3 years after implant loading

    Distribution of dental implants categorized into three status groups: healthy, peri-implant mucositis, and peri-implantitis based on clinical and radiographic criteria

Secondary outcomes

  1. Gingival Index (GI)

    Time frame: At least 3 years after implant loading

    Assessment of Gingival Index (GI) to evaluate the inflammatory status of peri-implant tissues.

  2. Plaque Index (PI)

    Time frame: At least 3 years after implant loading.

    Assessment of Plaque Index (PI) to evaluate the plaque accumulation around peri-implant tissues.

  3. Probing Depth (PD)

    Time frame: At least 3 years after implant loading.

    Assessment of Probing Depth (PD) to evaluate the pocket depth around peri-implant tissues.

Sponsors and collaborators

Lead sponsor

Inonu University

Other

Registry information

Official study title

The Effect of Systemic Factors on Peri-implant Health Status and Clinical Indices: A Cross-sectional Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 15, 2026
Registry last updated
Apr 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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