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NCT Number: NCT07722364

HFCWO in Children With Non-CF Bronchiectasis

the study will concentrate on the effect of High Frequency Chest Wall Oscillation compared to conventional pulmonary physiotherapy on children with non cystic fibrosis bronchiectasis

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Key information

Conditions

Non Cystic Fibrosis Bronchiectasis Bronchial Diseases Bronchiectasis Congenital, Hereditary, and Neonatal Diseases and Abnormalities Cystic Fibrosis Digestive System Diseases Genetic Diseases, Inborn Infant, Newborn, Diseases Lung Diseases Pancreatic Diseases Respiratory Tract Diseases

Age range

6 year–12 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

The purpose of this study is to evaluate the effect of using HFCWO intervention on pulmonary functions in children with bronchiectasis.

it hypothesized that Using HFCWO has no effect on pulmonary functions and hospital stay in children with bronchiectasis.

Children subjected to the inclusion criteria will be assigned randomly into two groups, control group and study group.

Does high frequency chest wall oscillation (HFCWO) have an effect in pulmonary functions in children with bronchiectasis? RCT study Control group Patients in this group will be 30 children who will be treated by conventional physiotherapy program directed towards improvement of pulmonary functions and quality of life.

Study group This group will include 30 children who will use HFCWO for 20 minutes, in addition to 10 minutes of the same conventional program of physiotherapy given to the control group.

The frequency of treatment will be 5 sessions/week for three successive months for both groups for long term effect and daily for immediate effect.

outcome measure: FEV1, FVC, FEV1/FVC quality of life for bronchiectasis, 6-minute walk test

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Children with no cystic fibrosis bronchiectasis
  • Both sexes
  • Their ages ranges from 6-12 years
  • After 48 hours of attack, if hemoptysis or fever not found

Exclusion criteria

  • • Osteoporosis (Calcium deficiency)
  • Bleeding tendency
  • Recent surgery of brain, eye, thoracic, or neck surgery
  • Pneumothorax
  • Cystic fibrosis bronchiectasis
  • Pulmonary embolism
  • Rib fracture

Treatment and study plan

High Frequency Chest Wall Oscillation

Device

High-frequency chest wall oscillation that applies external chest wall oscillations via an inflatable vest worn around the thoracic cage, increasing the air-liquid shear forces during expiration is believed to result in secretion mobilization.

The product name that will be used is Air Way Clearness system; his model is PV-900/ PV-300/PV-100, made in China.

conventional physiotherapy program directed towards improvement of pulmonary functions and quality of life.

Other

conventional physiotherapy program directed towards improvement of pulmonary functions and quality of life.

Conventional physiotherapy that will be applied to the control group for 30 minutes will include:

  • Postural drainage according to accumulation of secretions for 10 minutes accompanied by percussion or vibration
  • Active cycle breathing technique (ACBT) for 10 minutes
  • Respiratory exercises for 10 minutes

Primary outcomes

  1. Forced Expiratory Volume in 1 second (FEV1)

    Time frame: Baseline and after 8 weeks of treatment

    Change in FEV1 measured by spirometry according to ATS/ERS guidelines

  2. Forced Vital Capacity (FVC)

    Time frame: Baseline and after 6 months of treatment

    Change in FVC measured by spirometry according to ATS/ERS guidelines

  3. FEV1/FVC Ratio

    Time frame: Baseline and after 6 months of treatment

    Change in FEV1/FVC ratio measured by spirometry according to ATS/ERS guidelines

Secondary outcomes

  1. Six-Minute Walk Distance (6MWD)

    Time frame: Baseline and after 6 months of treatment

    hange in functional exercise capacity assessed by the Six-Minute Walk Test (6MWT). The total distance walked in six minutes is recorded according to the American Thoracic Society (ATS) guidelines.

Study contacts

Contact information is provided by the study sponsor or research team.

Marwa elkawy, Msc

CONTACT

[email protected]

01030077626

Sponsors and collaborators

Lead sponsor

Sphinx university

Other

Registry information

Official study title

Effect of High Frequency Chest Wall Oscillation on Pulmonary Functions in Children With Non-Cystic Fibrosis Bronchiectasis

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Jul 23, 2026
Registry last updated
Jul 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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