Heredity of Retinal Vessel Tortuosity

The purpose of this study is to asses the relative influence of genetic and environmental influence on the tortuosity of retinal arterioles in eyes of 218 healthy Danish twins aged 20-46 years. We expect to find a high heredity for the variation in tortuosity. This knowledge can contribute to the elucidation of the pathology in retinal diseases.

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Key information

Conditions

Retinopathy of Prematurity Congenital, Hereditary, and Neonatal Diseases and Abnormalities Eye Diseases Infant, Newborn, Diseases Infant, Premature, Diseases Retinal Diseases

Age range

20 year–46 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Ophthalmology Glostrup Hospital

Glostrup Municipality, Copenhagen County, DK-2600, Denmark

About this study

All persons underwent an ophthalmic examination including refraction, slit lamp biomicroscopy and digital fundus photography. Two independent graders (both with an MD degree) made a visual grading of the severity of tortuosity of the retinal arterioles in the fundus images.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Samesex twin pairs of self-assessed good health

Exclusion criteria

Diabetes mellitus
Hypertension
Thyroid disease
Cataract or other opacities of the refractive media
Missing fundus photographs

Sponsors and collaborators

Lead sponsor

Glostrup University Hospital, Copenhagen

Other

Collaborators

Juvenile Diabetes Research Foundation

Registry information

Official study title

Heredity of Retinal Vessel Tortuosity - A Twin Study

Important dates

Study start: 1998
Study completion: 1998
First posted: Jan 26, 2007
Registry last updated: Jan 26, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed