Hereditary Haemorrhagic Telangiectasia Flight Safety Study

Hereditary Haemorrhagic Telangiectasia (HHT) is a condition in which sufferers have abnormal blood vessels which makes them more likely to bleed than other people, particularly in the lungs, which results in low blood oxygen levels. Flying may make this worse and cause problems. The investigators want to know if there are an increased number of problems on flights compared to on land.

The investigators currently do not have any evidence based guidelines on air travel to best advice people who suffer with HHT. The investigators would therefore like to ask individuals who have HHT about their experience on a flight, using a postal questionnaire.

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Key information

Conditions

Hereditary Haemorrhagic Telangiectasia Cardiovascular Abnormalities Cardiovascular Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhagic Disorders Hemostatic Disorders Telangiectasia, Hereditary Hemorrhagic Telangiectasis Vascular Diseases Vascular Malformations

Age range

16 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

HammersmithHospital, Imperial College Healthcare NHS Trust

London, W12 0NN, United Kingdom

About this study

Individuals with Hereditary Haemorrhagic Telangiectasia (HHT) previously reviewed at HHTIC London will be sent an invitation to participate in a short questionnaire study.

Quantitative variables from the questionnaires for statistical analysis will be the number of individuals responding (and number of questionnaires sent out); number of flights taken and number of complications, subgrouped by type, and flight duration in hours. Complication rates will be expressed as proportion of person flight hours.

The quantitative data from the questionnaire will then be compared with quantitative data from patients' medical records using non parametric methods such as Mann Whitney for univariate analyses.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

HHT

Exclusion criteria

Unable to provide informed consent

Treatment and study plan

Aeroplane flight in the past- no active intervention for study

Other

Aeroplane flight(s) previously taken by study participants

Questionnaire

Other

Flight by aeroplane (previous)

Primary outcomes

HHT Patients Who by the Questionnaire Did or Did Not Self Report a Medical Complication During Flight

Time frame: Patient were asked to report all flights taken up until questionnaire completion aged 18-90 (mean 55)ys. 145 HHT-affected respondents had flown for 18,943 hours over 3,950 flights.

Of all patients who were sent the questionnaire, this comparison was limited to those who had taken a flight, either long haul or short haul.

Participants were compared as to whether they did or did not suffer a flight complication.

Sponsors and collaborators

Lead sponsor

Imperial College London

Other

Registry information

Official study title

A Questionnaire Based Study to Evaluate the Safety of Flying in Hereditary Haemorrhagic Telangiectasia (HHT)

Acronym: Flying and HHT

Important dates

Study start: 2010
Primary completion: 2011
Study completion: 2011
First posted: May 2, 2012
Registry last updated: Nov 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed