Hepcidin Levels in Preterm Infants

A recently isolated peptide hormone, hepcidin, is thought to be the principal regulator of iron homeostasis. Hepcidin acts by limiting intestinal iron absorption and promoting iron retention in reticuloendothelial cells. The aims of this study were to determine serum hepcidin levels in preterm infants who receive blood transfusion and preterm infants having sepsis, in order to assess possible relationships between hepcidin and serum iron, serum ferritin,in iron load situations.

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Key information

Conditions

Preterm Infants Anemia Anemia of Prematurity Congenital, Hereditary, and Neonatal Diseases and Abnormalities Hematologic Diseases Hemic and Lymphatic Diseases Infant, Newborn, Diseases Infections Inflammation Neonatal SEPSIS Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome

Age range

24 week–37 week

Sex eligibility

All sexes

Study type

Observational

Primary location

Neonatal Intensive Care Unit

Kfar Saba, 44281, Israel

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Preterm < 38 weeks gestation
Need of blood test for anemia or suspected sepsis

Exclusion criteria

Major congenital anomalies
Birth Asphyxia

Treatment and study plan

Primary outcomes

Increase in Hepcidin levels by 30%

Time frame: within 24-72 h

Sponsors and collaborators

Lead sponsor

Meir Medical Center

Other

Registry information

Official study title

Hepcidin Levels in Preterm Infants Receiving Blood Transfusion and During Sepsis.

Important dates

Study start: 2012
Primary completion: 2013
Study completion: 2013
First posted: Feb 27, 2012
Registry last updated: Mar 16, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed