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OpenTrials
Completed

NCT Number: NCT03171428

Hepatectomy With or Without the Thoraco-abdominal Approach

The performance of hepatectomy for liver tumors using the thoraco-abdominal approach (TAA) versus the abdominal approach (AA) is still debated.

The aim of the study is the analysis of the perioperative outcome of patients operated with or without the TAA for liver tumors.

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Key information

Conditions

Surgery Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Digestive System Diseases Digestive System Neoplasms Hepatectomy Liver Diseases Liver Neoplasms Liver Resection Liver Tumors Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

The prospectively maintained database was queried. A 1:1 propensity score-matched analysis was applied. Among 744 patients, 246 undergoing hepatectomy with TAA and 246 undergoing hepatectomy with AA were compared. These patients were matched for baseline characteristics, underlying liver disease, comorbidity, tumor features, and extent of the resection. The rates of morbidity and mortality were the study endpoints.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • First liver surgery;
  • Any type of malignant liver tumor, including hepatocellular carcinoma on cirrhosis.

Exclusion criteria

  • Previous history of liver surgery;
  • Any type of benign liver tumor;
  • Incomplete clinical, surgical, pathological or postoperative data;
  • Patients treated with radiofrequency ablation alone or in combination with surgery were also excluded.

Treatment and study plan

Hepatectomy

Procedure

Surgery for liver tumors is the removal of a part of the liver affected by a tumor.

Other names: hepatic resection; liver resection; liver surgery

Primary outcomes

  1. Short-term outcome: Occurrence of postoperative complications or death after surgery

    Time frame: Within 90-days after the operation

    Occurrence of postoperative complications or death after surgery

Sponsors and collaborators

Lead sponsor

University of Milan

Other

Registry information

Official study title

Hepatectomy With or Without the Thoraco-abdominal Approach: Impact on Perioperative Outcome

Important dates

Study start
2007
Primary completion
2013
Study completion
2015
First posted
May 31, 2017
Registry last updated
Jun 1, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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