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OpenTrials
Completed

NCT Number: NCT03178409

Combined HCC-MFCCC

Combined hepatocellular and mass-forming cholangiocarcinoma (cHCC-MFCCC) is a rare tumor. The aim of this study was the analysis of the outcome comparing such tumor with classic hepatocellular carcinoma (HCC) and mass-forming cholangiocarcinoma (MFCCC).

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Key information

Conditions

Liver Carcinoma Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Cholangiocarcinoma Digestive System Diseases Digestive System Neoplasms Hepatocellular Carcinoma Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

The institutional prospectively maintained database was queried, and 20 patients with cHCC-MFCCC were identified. A 2:1 match was performed with 40 patients operated in the same period for HCC, and with 40 operated for MFCCC. Only T1 or T2 patients N0 M0 were considered. Primary endpoint was the overall survival (OS) and disease-free survival (DFS).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • positive histology for cHCC-MFCCC, HCC, and MFCCC
  • complete clinical, surgical, pathological and follow-up data.

Exclusion criteria

  • patients preoperatively treated with chemotherapy, radiofrequency ablation or trans-arterial therapies were excluded.
  • patients operated for recurrent disease and/or with non-radical surgery
  • patients with missing data were also excluded

Treatment and study plan

Hepatectomy

Procedure

Removal of a part of the liver

Other names: Liver resection, Liver surgery

Primary outcomes

  1. Survival analysis

    Time frame: From 3 months after surgery up to 60 months after surgery

    Analysis of overall and disease-free survival of patients resected for cHCC-MFCCC versus those resected for HCC versus those resected for MFCCC

Sponsors and collaborators

Lead sponsor

University of Milan

Other

Registry information

Official study title

Survival After Hepatectomy for Combined Hepatocellular Cholagiocarcinoma

Important dates

Study start
2004
Primary completion
2014
Study completion
2017
First posted
Jun 6, 2017
Registry last updated
Jun 6, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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