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NCT Number: NCT07128862

Heavy-load Resistance Training With and Without Blood Flow Restriction Therapy in Athletes

A 8 weeks, single-blinded randomized controlled trial will be conducted at Pakistan Sports Board (PSB). Forty-four athletes (18-35 years) will be randomized into Group A (HL-RT + BFR, n = 22) and Group B (HL-RT only, n = 22). BFR will be applied at 50% limb occlusion pressure during lower-body exercises (squats, leg press). Both groups trained 3x/week for 4 weeks at 70-80% 1RM. Outcomes included 1RM strength, squat endurance, push-up performance, and International Physical Activity Questionnaire (IPAQ) scores.

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pakistan Sports Board

Lahore, Punjab Province, 54000, Pakistan

Location status: Recruiting

Location contact

Hafiz Amir

CONTACT

04299230383

Mubashra Waheed, DPT

PRINCIPAL_INVESTIGATOR

About this study

This study is a single-blinded randomized controlled trial (RCT) comparing heavy-load resistance training (HLRT) with blood flow restriction (BFR) versus HLRT alone. Participants will be blinded to group allocation, but outcome assessors will not remain blinded throughout the study.

Group A participants will perform three important exercises namely back squats, leg press, and bench press. Those exercises were performed at a training intensity ranging from 70-80% of each person's 1-repetition maximum (1RM). 12 cm pneumatic cuffs was placed proximally on the thigh (for exercise of lower body) and arm (for exercise of upper body), and blood flow restriction was applied through them. Doppler ultrasound was used weekly to measure limb occlusion pressure (LOP) to then set the cuff pressure at 50% of each participant's predetermined LOP. During working sets it was made the cuffs inflated but during rest periods they were deflated. The exercise protocol consists of:

  • Back squats: 4 sets of 6 repetitions
  • Leg press: 3 sets of 8 repetitions
  • Bench press: 3 sets of 10 repetitions All sets will be followed by a standardized 2-minute rest period. Training load will progressively increased by 2.5-5% when participants can complete all prescribed repetitions with proper form for two consecutive sessions.

Group B: Heavy-Load Resistance Training Only (HLRT) This control group will perform the identical exercise protocol (same exercises, intensities, volumes, and rest periods) as the BFR group, but without any blood flow restriction application. The same progression criteria will be used for both groups to ensure comparable training stimulus.

Post-Intervention Data Collection (Week 4)

Following the 4-week intervention period, all participants were undergone reassessment using the same measures collected at baseline:

  • 1RM testing for back squat and bench press
  • Muscular endurance tests (max repetition squat test and 1-minute push-up test)
  • International Physical Activity Questionnaire (IPAQ)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants with age between 18 and 35 years.
  • Active individual participating in sport activities at least 3 times a week for the past 6 months.
  • Participants with any non-heart conditions.
  • Individuals voluntarily participating and providing informed consent.
  • Sprinters, Footballer

Exclusion criteria

  • Individuals with DVT or other pulmonary artery disease.
  • Pregnant women or those planning to become pregnant.
  • Participants with recent musculoskeletal injuries (within the 6 months).
  • Individuals currently involved in another study.
  • Participants allergic to or sensitive to the materials used in the BFR bands.
  • Individuals who anticipate being unable to attend all training sessions.

Treatment and study plan

Heavy-Load Resistance Training with Blood Flow Restriction

Other

Blood Flow Restriction (BFR) Training (also known as "Kaatsu" training is an innovative and increasingly popular exercise technique to improve muscle strength and hypertrophy with relatively low loads. Heavy Load Resistance Training (HL-RT) is one of the most effective exercise methodology that is widely used to increase muscular strength and hypertrophy.

Heavy-Load Resistance Training Only

Other

Heavy Load Resistance Training (HL-RT) is one of the most effective exercise methodology that is widely used to increase muscular strength and hypertrophy.

Primary outcomes

  1. 1RM strength

    Time frame: 6 weeks

    The 1 Repetition Maximum (1 RM) Testing protocol determines quadriceps maximal strength through identifying the maximum weight an individual can lift in a single attempt with exercises that include the leg press or squat and leg extension movements.

  2. Squat Endurance

    Time frame: 6 weeks

    Experts have established the validity of 3-5 RM squats as a strength test because they correlate strongly with quadriceps force output and exhibit excellent reliability (ICC > 0.90) through standardization of stance and depth and rest periods. Maximal bodyweight squats at 60-70% 1 RM or to complete failure serve as reliable (ICC ~0.70-0.85) and moderate tests of endurance even though hip and core involvement affects validity.

  3. Push Up Performance

    Time frame: 6 weeks

    The push-up test is largely used to evaluate upper body endurance and strength (chest, shoulders, triceps) without much activation of the quadriceps and should not be considered as an indicator of quad endurance or strength. On standard push ups though, quads serve only as stabilizers which means it does not provide much of contribution than exercise such as squatting or doing leg extensions. Push-ups can still be considered a reliable test (ICC ~0.80-0.90) for upper body muscular endurance but cannot be used to assess quadriceps function

  4. International Physical Activity Questionnaire (IPAQ) scores

    Time frame: 6 weeks

    International Physical Activity Questionnaire (IPAQ). Interpretation: Higher score indicates increased physical activity in athletes. Effect of interpretation: BFR with heavy load training significantly increases physical activity levels as compared to control.

    Description: The International Physical Activity Questionnaire - short form (IPAQ-SF) will be used to assess a participant's total physical activity levels. This self-report tool estimates MET-minutes per week across various domains. The score ranges from 0 to an upper limit, with higher scores indicating greater levels of physical activity.

Study contacts

Contact information is provided by the study sponsor or research team.

Imran Amjad, Phd PT

CONTACT

[email protected]

03324390125

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Effects of Heavy-load Resistance Training With and Without Blood Flow Restriction Therapy on Quadriceps Muscle Strength and Endurance in Athletes

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 19, 2025
Registry last updated
Aug 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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