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NCT Number: NCT06551168

Heat Acclimation in Females

Heat acclimation is when you repeatedly exposure yourself to heat so that your body adapts and better tolerates heat.

This project will determine if completing a heat acclimation maintenance period after heat acclimation is more beneficial than heat acclimating alone for exercise performance in the heat. To determine this, participants will exercise in the heat before heat acclimation, after heat acclimation, and after heat acclimation maintenance. Researchers will assess the heart's pumping capacity, blood volume, body temperature, and exercise performance to determine which approach is more effective.

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Key information

Age range

18 year–55 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Trinity Western Unversity

Langley, British Columbia, V2Y 1Y1, Canada

Location status: Recruiting

Location contact

Anita T Cote, PhD

CONTACT

[email protected]

1 604-513-2121 ext. 3726

About this study

Purpose and Hypothesis: Global warming combined with increased frequency of heat waves exposes those who are working, exercising, or competing outdoors to considerable thermal strain. Excessive heat stress decreases exercise performance and can lead to heat illnesses. Deliberate serial exposure to natural (acclimatization) or artificial (acclimation) heat (HA) is the most efficacious method to defend homeostasis at rest and during exercise in hot environments. Our project will determine if three weeks of heat acclimation maintenance (HAM) further potentiates exercise performance in the heat than exercise performance measured after 10 days of HA in females.

Justification: Female participation in arduous occupations and professional sport is increasing. Presently a paucity of data regarding the female response to heat acclimation exist. Findings from this study will help females undertake effective and efficient strategies to mitigate thermal strain.

Research design: This is an experimental trial with a treatment and a control group. VO2max, plasma volume (PV), core temperature, and cardiac output will be measured pre-, mid-, and post-intervention. Participants will complete 10 sessions of HA over two weeks. Participants will then undergo three weeks of HAM with three heat sessions per week. A heat performance test will be completed pre-, mid-, and post-intervention to examine performance changes. A control group will complete the same test schedule but will not perform any HA or HAM.

Statistical analysis: Sample size will be 8 females in the experimental and 6 females in the control group. Data will be analyzed for normality using the Shapiro-Wilk test. Descriptive statistics will be presented as the mean and standard deviation. Statistical significance will be determined at P <0.05. A two-way repeated measure ANOVA will be used to measure differences between groups and hemodynamic, cardiovascular and performance variable differences pre- and post-HA, and pre- post-HAM. If significant effects are present, these will be followed by a post-hoc Tukey's test. Pearson's r correlations (two-tailed) will be conducted between VO2max, and intravascular volumes and heat performance test outcome.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Familiar with the sport of cycling and own a bicycle and smart trainer (or a trainer and a power meter).
  • Endurance athlete or currently engaging in endurance exercise
  • Maximal oxygen consumption (VO2max) greater than 40 ml/kg/min
  • Between the ages of 18 and 55
  • Able to speak, read, and write in English

Exclusion criteria

  • Unable to exercise
  • Previous or current heat intolerance
  • Pregnant

Treatment and study plan

Heat exposure

Other

Participants will exercise at home while wearing a clothing ensemble over 19 one hour sessions. They will use validated perceptual scales to guide their effort and thermal sensation.

Control Group

Other

Participants will exercise at home over 19 one hour sessions. They will use heart rate to guide their effort. The exercise will take place in cool conditions

Primary outcomes

  1. Performance

    Time frame: 2 weeks and 5 weeks

    Participants will complete a timetrial on a cycle ergometer in a heat chamber. Faster times following HA or HAM will be considered a marker of performance

Secondary outcomes

  1. Intravascular volumes

    Time frame: 2 weeks and 5 weeks

    Expanded plasma volume or increased hemoglobin mass will be considered a positive response to heat acclimation

Study contacts

Contact information is provided by the study sponsor or research team.

Anita T Coté, PhD

CONTACT

[email protected]

604.513.2121 ext. 3726

Normand A Richard, MSc

CONTACT

[email protected]

604.513.2121 ext. 3726

Sponsors and collaborators

Lead sponsor

Trinity Western University

Other

Registry information

Official study title

The Cardiovascular, Hematological, and Performance Response to Heat Acclimation in Healthy Trained Females

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Aug 13, 2024
Registry last updated
Apr 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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