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Completed

NCT Number: NCT03393728

Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol

Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism.

Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).

Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours.

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Key information

Conditions

Hyperthyroidism Endocrine System Diseases Thyroid Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

About this study

Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism.

Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).

Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours. Other outcomes included mean heart rate, mean R-R interval during 2-hour rest.

The study questions the systematic adjunction of Propanolol early in the treatment of hyperthyroidism.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • consenting patients referred to or diagnosed at the National Centre of Obesity of the Yaounde Central Hospital as having hyperthyroidism
  • naïve of all treatment specific for hyperthyroidism.
  • aged 18-70 years

Exclusion criteria

  • Patients already under a specific treatment for hyperthyroidism
  • Patients taking beta blockers or any other cardiospecific treatment
  • Patients presenting complications including acute thyrotoxic crisis, or symptomatic cardiac failure
  • Contraindications to the prescription of beta blockers

Treatment and study plan

Propanolol

Drug

72-hour propanolol before specific treatment of hyperthyroidism

Other names: Avlocardyl

Primary outcomes

  1. Heart rate variability

    Time frame: 72 hours

    Sympatho vagal tone measures

Secondary outcomes

  1. Heart rate

    Time frame: 72 hours

    Heart rate

Sponsors and collaborators

Lead sponsor

Yaounde Central Hospital

Other Gov

Registry information

Official study title

Short Term Effects of Propanolol on Heart Rate Variability of Hyperthyroidism

Important dates

Study start
2008
Primary completion
2008
Study completion
2009
First posted
Jan 8, 2018
Registry last updated
Jan 8, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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