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Completed

NCT Number: NCT06034132

Healing Abutment Materials on Matrix Metalloproteinase-8 Level in Peri-implant Crevicular Fluid

Numerous materials are nowadays used in the fabrication of healing abutments to be used for dental implants. soft tissue response to different healing abutment materials is still to be unraveled. the Aim of this study is to compare the soft tissue response to titanium stock healing abutments to customized composite healing abutments through assessing the level of matrix metalloproteinase-8 in the peri-implant crevicular fluid

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Key information

Conditions

Dental Implants

Age range

25 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Alexandria Faculty of Dentistry

Alexandria, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with no systemic and/or oral health disease
  • absence of any lesions in the oral cavity
  • wide band of keratinized tissue more than 1mm at implant site

Exclusion criteria

  • smoking more than 20 cigarettes per day
  • localized radiation therapy of the oral cavity,
  • antitumor chemotherapy, liver diseases, blood diseases, kidney diseases, immunosuppressed patients, patients taking corticosteroids, pregnancy, inflammatory and autoimmune diseases of the oral cavity

Treatment and study plan

Stock healing abutments

Other

2ND stage surgery will be performed and stock healing abutment were placed

Compoiste healing abutments

Other

2ND stage surgery will be performed and composite healing abutment were placed

Primary outcomes

  1. Change in MMP8 levels

    Time frame: at 2 weeks and 4 weeks

    Measuring MMP-8 level around composite and titanium healing abutments with ELISA kit

Secondary outcomes

  1. Change in gingival condition

    Time frame: at 2 weeks and 4 weeks

    Modified gingival index was used to assess gingival condition The MGI uses a rating score between 0 and 4 0 = absence of inflammation

    • = mild inflammation
    • = mild inflammation
    • = moderate inflmmation
    • = severe inflammation

  2. Change in gingival bleeding

    Time frame: at 2 weeks and 4 weeks

    Bleeding index will be recorded as present or absent

  3. Change in plaque accumulation

    Time frame: at 2 weeks and 4 weeks

    Plaque index 0: No plaque is in the area adjacent to the gingiva. Plaque index 1: There is a plaque in the form of a thin film on the gingival margin.

    Plaque index 2: There is a visible plaque in the gingival pocket and gingival margin.

    Plaque index 3: There is a dense plaque in the gingival pocket and on the gingival margin.

Sponsors and collaborators

Lead sponsor

Alexandria University

Other

Registry information

Official study title

Effect of Two Different Healing Abutment Materials on Matrix Metalloproteinase-8 Level in Peri-implant Crevicular Fluid (a Randomised Clinical Trial)

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Sep 13, 2023
Registry last updated
Sep 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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